Cross-reactivity between Candida albicans and human ovarian carcinoma as revealed by monoclonal antibodies PA10F and C6

British Journal of Cancer
J SchneiderJ Pontón

Abstract

Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and immunohistochemistry. We have subsequently used one of them, PA10OF, to test by means of immunohistochemistry a series of 37 human ovarian carcinomas. Out of 37 tumours, 25 (67.6%) expressed the antigen recognized by PA1OF. The reactivity, however, was concentrated on the subgroup of particularly aggressive, invasive carcinomas in advanced stages of the disease (19 out of 24 positive), whereas the antigen was expressed significantly less (P=0.0007) in the subgroup of much less aggressive stage I tumours of low malignant potential, also called borderline carcinomas (2 out of 13 positive). This cross-reactivity between C. albicans and ovarian carcinoma seems to be attributable to a common antigenic determinant related to tumour aggressiveness.

Citations

Mar 5, 2004·International Journal of Cancer. Journal International Du Cancer·David AgudoJosé Schneider
Feb 1, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Yong ZhangXiao-Feng Sun
Jan 1, 2013·Acta Pharmacologica Sinica·Li-jing Yang, Yan Chen
Feb 18, 2012·Nature Reviews. Cancer·Kin-Hoe ChowKatharine S Ullman
Sep 6, 2012·International Journal of Molecular Sciences·Miroslava Jankovic, Ninoslav Mitic
Apr 20, 2016·Critical Reviews in Biotechnology·Mohammadali SafaviehWaseem Asghar
Aug 23, 2017·Expert Review of Anti-infective Therapy·Wilfried PoschCornelia Lass-Flörl
May 30, 2019·International Journal of Molecular Sciences·Maria Alvarado-Kristensson, Catalina Ana Rosselló
Jul 7, 2009·Seminars in Cell & Developmental Biology·Songli Xu, Maureen A Powers

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