PMID: 8589666Oct 1, 1995Paper

Cross-reactivity between human sialyl Lewis(x) oligosaccharide and common causative oral bacteria of infective endocarditis

FEMS Immunology and Medical Microbiology
Katsuhiko HirotaY Miyake

Abstract

The expression of sialy-Lewis(x) (sLe(x); Neu5Ac alpha 2-3 Gal beta 1-4) (Fuc alpha 1-3) GlcNAc-R) on oral bacteria producing infective endocarditis was determined by a whole-cell enzyme linked immunosorbent assay and an immunoelectron microscopy using the well-characterized anti-sLe(x) monoclonal antibody SNH-3 (mAb SNH-3; IgM class). mAb SNH-3 reacted strongly with whole cells of oral bacteria: Streptococcus sanguis, Streptococcus mutans, Streptococcus mitis, Streptococcus salivarius, Streptococcus intermedius, Streptococcus constellatus, Streptococcus anginosus, Streptococcus pyogenes, Actinobacillus actinomycetemcomitans, Eikenella corrodens and Porphyromonas gingivalis. The negatively stained immuno-electron micrograph of Streptococcus pyogenes showed many reactive gold particles on the cell surface. Our findings demonstrated the existence of immunologic mimicry between the sLe(x) oligosaccharide and cell surface antigens of many species associated with infective endocarditis. We propose the hypothesis that if these bacteria escape their normal habitats, the surface components that mimic the sLe(x) oligosaccharide might bind to host antigens of the selectin family which could promote binding to endothelial cells and, conse...Continue Reading

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Citations

Feb 3, 2012·Biological Reviews of the Cambridge Philosophical Society·Annemarie Boleij, Harold Tjalsma
Jul 9, 2013·The Lancet Infectious Diseases·Annemarie Boleij, Harold Tjalsma
Mar 25, 2010·Cellular Microbiology·Joao H F PedraErol Fikrig
Jan 24, 2007·Brazilian Oral Research·Antonio Carlos Victor CanettieriCarmelinda Schmidt Unterkircher
Sep 16, 2006·Glycobiology·Bing MaDiane E Taylor
May 23, 2014·Molecular Oral Microbiology·D Asam, B Spellerberg
Apr 1, 1997·Immunology and Cell Biology·J M Davies
Dec 31, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rebecca E Oberley, Jeanne M Snyder
Jun 28, 2017·World Journal of Gastroenterology : WJG·Magdalena Chmiela, Weronika Gonciarz
May 21, 1998·Antimicrobial Agents and Chemotherapy·K HirotaY Miyake

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