Cross-reactivity between myelin oligodendrocyte glycoprotein and human endogenous retrovirus W protein: nanotechnological evidence for the potential trigger of multiple sclerosis

Micron : the International Research and Review Journal for Microscopy
Vanessa de LucaFabio Lima Leite

Abstract

Multiple sclerosis (MS) is an autoimmune and inflammatory demyelinating disease of the central nervous system. Experimental evidence supports the reactivity of autoantibodies against components of myelin sheath including the myelin oligodendrocyte glycoprotein (MOG). The MS etiology is still unknown, but some risk factors associated with immune dysregulation, genetic susceptibility, and environmental factors are under investigation. The last consider the hypothesis of molecular mimicry mechanism, which is potentially triggered by viral antigen inducing MS autoimmunity. The Human Endogenous Retroviruses W family (HERV-W) is the subject of studies within this field, based on the detection of HERV-W envelope gene proteins in MS patients' samples. In the biomedical field of diagnosis and therapeutics, nanotechnology is of great use for the detailed study of molecular mechanisms involving specific interactions between biomolecules providing high specificity and sensitivity of response. In view of the significance of etiological aspects for the comprehension of MS mechanisms of action, we applied a nanotechnological approach designed for antibody detection. For this, we analyzed MOG peptide sequences similar to the HERV-W protein. Th...Continue Reading

Citations

Jul 30, 2019·Frontiers in Genetics·Joel GruchotPatrick Küry
Jun 18, 2020·Viruses·Rachael E TarlintonSubhash Verma
Jan 14, 2021·Annals of Clinical and Translational Neurology·Aparna N GovindanScott W Wong
Dec 17, 2021·Frontiers in Immunology·Silvia Pérez-PérezRoberto Álvarez-Lafuente

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