Cross-reactivity between thiurams

Contact Dermatitis
Anne LerbaekBodil Knudsen

Abstract

Retesting with an allergen at a site with previous allergic contact dermatitis has been shown to enhance reactivity. It has been suggested that retesting with a cross-reactive allergen will also induce hyperreactivity. Concurrent sensitization to more than 1 thiuram is common, but whether this is due to concomitant primary sensitization or cross-reactivity is uncertain. The aim of this study was to investigate the use of retesting to distinguish between concomitant sensitization and cross-reactivity in the rubber chemicals tetraethylthiuram disulphide (TETD) and tetramethylthiuram disulphide (TMTD). There was a non-significant trend towards enhanced reactivity for both TETD and TMTD when testing in an area with previous allergic contact dermatitis due to TETD. Cross-reactivity between the 2 chemicals is likely, but a definite conclusion from this pilot study is not possible.

References

Aug 1, 1993·Journal of the American Academy of Dermatology·L Conde-SalazarA González Domingo
Mar 17, 2001·The British Journal of Dermatology·K L GibbonI R White
Sep 13, 2001·Contact Dermatitis·S D MorrisR J Rycroft
Jul 10, 2002·Experimental Dermatology·Thomas RustemeyerRik J Scheper
Mar 19, 2003·Contact Dermatitis·Johannes GeierUNKNOWN Information Network of Departments of Dermatology (IVDK)

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Citations

Jan 25, 2007·Contact Dermatitis·Monica CorazzaAnnarosa Virgili
Sep 13, 2011·Contact Dermatitis·Claudia PföhlerThomas Vogt
Jan 15, 2009·Immunology and Allergy Clinics of North America·Peter A L Bonis
Mar 25, 2015·Contact Dermatitis·Kris CreytensAn Goossens

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