PMID: 6968871Nov 13, 1980Paper

Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line

Nature
L Y Lu, B A Askonas

Abstract

Spleen cytotoxic T cells killing influenza virus-infected target cells are cross-reactive for the different type A influenza viruses, in contrast to the circulating antibodies, which show fine specificity for each A virus subtype variant. This finding has raised the question of whether a single T cell can recognize cells infected with all type A viruses. T-killer cell lines with specificity for alloantigens and the male Y antigen can be selected by means of growth factors present in the supernatant of T cells stimulated with concanavalin A (refs 3-7). We report here that we have been able to establish clones of mouse T cells killing target cells infected with influenza virus. Our cell line maintains the same specificity as the heterogeneous spleen cell population from infected mice, in as far as the T-killer cells are specific for A influenza virus, but do not discriminate between the different type A viruses. The cell line maintains H-2 restriction and does not kill cells infected with B influenza virus. The cells grow in the presence of T-cell growth factor and do not require antigen for growth although they maintain their receptors for type A virus. They can also be stimulated by irradiated T-helper cells from mice primed by...Continue Reading

References

Aug 1, 1979·European Journal of Immunology·H von BoehmerW Haas
Jul 14, 1977·Nature·S Gillis, K A Smith
Nov 1, 1979·The Journal of Experimental Medicine·R B Ashman, A Müllbacher
Oct 1, 1978·The Journal of Experimental Medicine·S GillisK A Smith
Jan 1, 1978·Contemporary Topics in Molecular Immunology·T J BracialeK L Yap
Apr 1, 1980·The Journal of Experimental Medicine·U H KoszinowskiH D Klenk
Apr 1, 1980·The Journal of Experimental Medicine·A L Glasebrook, F W Fitch

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Citations

Jan 1, 1983·Immunogenetics·A R TownsendB A Askonas
Jan 1, 1982·Medical Microbiology and Immunology·D ArmerdingE Liehl
Sep 1, 1985·Cellular Immunology·G SterkersJ P Lévy
May 1, 1989·Research in Immunology·M W KieranA Israel
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M ImawariH Nakagama
Oct 1, 1982·The Journal of Experimental Medicine·H D EngersG D Sorenson
Jan 1, 1981·Immunological Reviews·R M Zinkernagel, K L Rosenthal
Nov 1, 1981·Immunology Today·G L Ada
Oct 16, 2004·Expert Review of Anti-infective Therapy·Suzanne L Epstein
May 1, 1984·Journal of Virology·H C Ertl, R W Finberg

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