Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
C RavanatC Legrand

Abstract

The aim of the present study was to investigate the reactivity of immunoreagents developed for clinical applications in humans in different animal species (hen, mouse, rat, rabbit, guinea-pig, dog, pig, sheep, baboon). Prothrombin fragment 1 + 2, thrombin-antithrombin III complex and fibrinopeptide A were tested for coagulation, platelet factor 4 and beta-thromboglobulin for platelet activation, glycoprotein IIb-IIIa, glycoprotein Ib and P-selectin for platelet membrane glycoproteins, D-dimers for fibrinolysis, thrombomodulin for activation of endothelial cells and thrombospondin and von Willebrand factor for adhesive proteins. Prothrombin fragment 1 + 2, platelet factor 4, beta-thromboglobulin and D-dimers were revealed only in baboons. Fibrinopeptide A was well detected in baboons but weakly in mice, dogs, pigs and sheep. Whereas glycoprotein IIb-IIIa was revealed on guinea-pig, dog and sheep platelets and glycoprotein Ib on rabbit and dog platelets, P-selectin and thrombomodulin were never detected. Thrombospondin was revealed in hens, mice, rats, guinea-pigs, pigs, sheep and baboons and von Willebrand factor in mice, rats, guinea-pigs, dogs, pigs, sheep and baboons. Interestingly, thrombin-antithrombin III complex (TAT) was...Continue Reading

Citations

Nov 17, 2009·Journal of Veterinary Internal Medicine·R TsuchiyaT Yamada
Dec 13, 2005·Thrombosis Journal·Maike UnruhClaudia Gottstein
Oct 27, 2004·The Veterinary Journal·Patricia A Gentry
Nov 20, 2003·Resuscitation·Jakob JohanssonSten Rubertsson
Jun 16, 2014·Thrombosis Research·Samuel R FoleyYoke Lin Fung
Mar 10, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hiroko SatoKimimasa Takahashi
Jan 11, 2011·Thrombosis Research·Line Olrik BerthelsenMikael Tranholm
Jun 5, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Emily CozziRuth Ann Henriksen
Dec 20, 2005·Journal of Thrombosis and Haemostasis : JTH·A SchlachtermanV R Arruda
May 10, 2008·Journal of Veterinary Internal Medicine·T StokolA L Gelzer
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·M P ReillyS E McKenzie
Jun 8, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·T KnudsenM Tranholm
Jan 13, 2006·Thrombosis Research·Deborah A LewisThomas L Ortel
May 29, 2013·Veterinary and Comparative Oncology·A KolD L Borjesson
Mar 17, 2004·The Journal of Toxicological Sciences·Masaaki Kurata, Ikuo Horii
Apr 2, 2004·The Journal of Clinical Investigation·Paris MargaritisKatherine A High
Jul 9, 2009·Acta Veterinaria Hungarica·Renata Barić RafajVladimir Mrljak
Oct 29, 1998·The Journal of Surgical Research·T M FruchtermanR N Garrison
Oct 12, 2000·Toxicologic Pathology·S J NewsholmeL W Schwartz
Jun 28, 2005·The Veterinary Record·H MaruyamaM Tokuriki
Jun 14, 2002·American Journal of Veterinary Research·Janene K KingstonK Jane Wardrop
Feb 13, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sarmina HassanRobert W Colman
Nov 20, 2004·Blood·Joerg SchuettrumpfValder R Arruda
Jan 25, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Pierre PottierNorbert Passuti
Apr 17, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A K OlsenP Marckmann
Jul 9, 1998·Neural Computation·J A ReggiaY Shkuro
Feb 15, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ruedger KoppDietrich Henzler
Mar 7, 2002·The Journal of Nutrition·Aage K OlsenPeter Marckmann
Sep 10, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P PottierN Passuti
Jun 21, 2017·BMC Veterinary Research·Franck JolivetOlivier Dossin
Oct 12, 2018·Journal of Veterinary Emergency and Critical Care·Erin M MaysRita M Hanel
Jul 4, 2003·The Journal of Nutrition·Liselotte Sabroe EbbesenJørgen Ingerslev
Feb 13, 2021·Animals : an Open Access Journal From MDPI·Arianna MiglioMaria Teresa Antognoni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.