PMID: 9421107Jan 8, 1998Paper

Cross-reactivity of TDX and OPUS immunoassay systems for serum digoxin determination

Therapeutic Drug Monitoring
M OkazakiK Okumura

Abstract

The properties of the widely used TDX Analyzer and recently developed OPUS Immunoassay System were compared using 403 serum specimens taken from patients who did or did not take digoxin. Of the 210 specimens from patients not treated with digoxin, a false- positive digoxin concentration was detected in 15 specimens (7%) by TDX and in only 2 specimens (1%) by OPUS because of the cross-reactivity with structurally similar drugs. Potassium canrenoate, digitoxin, deslanoside, and methyldigoxin exhibited marked concentration-dependent cross-reactivity in the TDX assay method, whereas deslanoside and methyldigoxin only showed cross-reactivity with the antibody used in the OPUS method. Although a poor correlation was observed between these two methods for the determination of 193 samples from patients treated with digoxin, the correlation was remarkably improved (r = 0.914) and the slope approximated unity when excluded the data from patients who were treated concurrently with the cross-reactive compounds. In routine TDM of digoxin, the authors experienced two cases in which cross-reactivity of the assay system caused a clinical problem. Concurrent administration of intravenous canrenoate apparently interfered with the digoxin assay b...Continue Reading

References

Jan 1, 1990·Therapeutic Drug Monitoring·G N Foukaridis
Mar 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·A P Phillips
Nov 1, 1983·Annals of Internal Medicine·S W GravesR Valdes
Feb 1, 1995·Therapeutic Drug Monitoring·H M DoddsS M Pond

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Citations

Nov 23, 2010·Journal of Clinical Laboratory Analysis·Amitava Dasgupta, Myrtle J Johnson
May 10, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Marie DeguigneBénédicte Lelièvre
Mar 11, 2010·Therapeutic Drug Monitoring·Ana CoboMaria Mar Fernández de Gatta

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