PMID: 7515334Jun 1, 1994Paper

Cross-reactivity to proteoglycans in bacterial arthritis: lack of evidence for in vivo role in induction of disease

Clinical Immunology and Immunopathology
A G van de LangerijtW B van Den Berg

Abstract

Cross-reactivity between bacterial epitopes and cartilage components has been assumed to play a role in the pathology of bacterial-induced arthritis models. In this study, we report prominent proteoglycan (PG) depletion in Safranin-O stained ankle joint sections from collagen-induced arthritic rats. In adjuvant arthritis and streptococcal cell wall-induced arthritis (SCW-A), however, only limited PG degradation was observed. In vitro, PG fractions were able to stimulate T lymphocytes from these arthritic rats. To investigate the contribution of cross-reactivity, Lewis rats were primed with SCW in Freund's incomplete adjuvant (SCW/FIA). This immunization protocol resulted in in vitro stimulatory responses to the SCW antigens and cartilage PG antigens, but not to joint inflammation per se. Next, papain was injected intraarticularly to create a situation in which a large amount of potential cross-reactive cartilage epitopes are released. Interestingly, no inflammatory reaction could be observed in the papain-injected joints of SCW/FIA-primed rats. These data suggest that cross-reactivity between bacterial epitopes and PG does not seem to be a key element in the onset of joint inflammation in bacterial-induced arthritis. However, i...Continue Reading

Citations

May 1, 1997·Journal of Neuroimmunology·M Zhao, S S Atherton
Feb 22, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kazuhiko HarutaYoshinari Takasaki
Apr 25, 2008·Current Protocols in Immunology·R L Wilder

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