Cross-resistance of Pseudomonas aeruginosa to ciprofloxacin, extended-spectrum beta-lactams, and aminoglycosides and susceptibility to antibiotic combinations.

Antimicrobial Agents and Chemotherapy
A W ChowH G Stiver

Abstract

The susceptibilities of 270 clinical isolates of Pseudomonas aeruginosa from diverse sources (82 burn patients, 76 cystic fibrosis [CF] patients, and 112 other sources) to ciprofloxacin and three other quinolones, nine extended-spectrum beta-lactams, and three aminoglycosides were determined by an agar dilution method in cation-supplemented Mueller-Hinton medium. Ciprofloxacin, ceftazidime, imipenem, and aztreonam were the most active. MICs for burn isolates were consistently higher than those for other isolates for most antibiotics, whereas those for CF strains were consistently lower. Multidrug resistance to aminoglycosides and beta-lactams occurred in 21% of the burn isolates, 2.6% of the CF isolates, and 8.9% of the other isolates. Ninety percent of these strains remained susceptible to ciprofloxacin. Seven percent of the isolates were resistant to ciprofloxacin (MIC, greater than or equal to 2 micrograms/ml). Concurrent resistance to ciprofloxacin and beta-lactams or aminoglycosides was rare (1.8 to 4%). Analysis by Spearman rank correlation revealed a high degree of correlation of MICs among antibiotics within the same class, except for imipenem. An inoculum effect was observed for all antibiotics between 10(6) and 10(4) ...Continue Reading

References

Jul 1, 1986·Journal of Clinical Microbiology·H M PollockS B Forsythe
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·H Giamarellou, G Petrikkos
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·G M EliopoulosR C Moellering
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·N X Chin, H C Neu
Jul 1, 1984·Antimicrobial Agents and Chemotherapy·R H EngC Cherubin
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·G M EliopoulosR C Moellering
Apr 1, 1984·Antimicrobial Agents and Chemotherapy·D L Van Caekenberghe, S R Pattyn
Oct 1, 1981·The Journal of Antimicrobial Chemotherapy·S A SahnL B Reller

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Citations

Jul 1, 1992·Diagnostic Microbiology and Infectious Disease·L J Eron, L O Gentry
Mar 1, 1993·The Journal of Pharmacy and Pharmacology·R M Richards, D K Xing
Jun 7, 2019·The Journal of Antimicrobial Chemotherapy·Justin R Lenhard, Zackery P Bulman
Jan 1, 1996·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Isamu SaikawaYasuo Watanabe

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