Apr 30, 2020

Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility

BioRxiv : the Preprint Server for Biology
S. HarveyJ. Steinbrenner


Hyaloperonospora arabidopsidis (Hpa) is an oomycete pathogen causing Arabidopsis downy mildew. Effector proteins secreted from the pathogen into the plant play key roles in promoting infection by suppressing plant immunity and manipulating the host to the pathogens advantage. One class of oomycete effectors share a conserved RxLR motif critical for their translocation into the host cell. Here we characterize the interaction between an RxLR effector, HaRxL21 (RxL21), and the Arabidopsis transcriptional co-repressor Topless (TPL). We establish that RxL21 and TPL interact via an EAR motif at the C-terminus of the effector, mimicking the host plant mechanism for recruiting TPL to sites of transcriptional repression. We show that this motif, and hence interaction with TPL, is necessary for the virulence function of the effector. Furthermore, we provide evidence that RxL21 uses the interaction with TPL, and its close relative TPL-related 1, to repress plant immunity and enhance host susceptibility to both biotrophic and necrotrophic pathogens.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Pathogenic Organism
Virus Replication
Cross Reactions
Disease Transmission
Emergencies [Disease/Finding]
Mutation Abnormality
Population Group

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Miran ParkJames O Lloyd-Smith
The New Phytologist
Francis M MartinMarc-André Selosse
Proceedings of the National Academy of Sciences of the United States of America
Debra P C PetersKris M Havstad
© 2020 Meta ULC. All rights reserved