Cross-sectional and longitudinal analyses of the association between lung function and exercise capacity in healthy Norwegian men

BMC Pulmonary Medicine
Amir FarkhooyAndrei Malinovschi

Abstract

It is widely accepted that exercise capacity in healthy individuals is limited by the cardiac function, while the respiratory system is considered oversized. Although there is physiological, age-related decline in both lung function and physical capacity, the association between decline in lung function and decline in exercise capacity is little studied. Therefore, we examined the longitudinal association between lung function indices and exercise capacity, assessed by the total amount of work performed on a standardized incremental test, in a cohort of middle-aged men. A total of 745 men between 40 and 59 years were examined using spirometry and standardized bicycle exercise ECG test within "The Oslo Ischemia Study," at two time points: once during 1972-1975, and again, approximately 16 years later, during 1989-1990. The subjects exercise capacity was assessed as physical fitness i.e. the total bicycle work (in Joules) at all workloads divided by bodyweight (in kg). Higher FEV1, FVC and PEF values related to higher physical fitness at both baseline and follow-up (all p values < 0.05). Higher explanatory values were found at follow-up than baseline for FEV1 (r2 = 0.16 vs. r2 = 0.03), FVC (r2 = 0.14 vs. r2 = 0.03) and PEF (r2 = ...Continue Reading

References

Jun 25, 1977·British Medical Journal·C Fletcher, R Peto
Feb 25, 1993·The New England Journal of Medicine·L SandvikK Rodahl
Jan 1, 1996·Annual Review of Physiology·P D Wagner
Dec 1, 1996·The European Respiratory Journal·H Guénard, R Marthan
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·T G BabbJ R Rodarte
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·D S DeLorey, T G Babb
Jan 27, 2000·Medicine and Science in Sports and Exercise·D R Bassett, E T Howley
Nov 15, 2000·Journal of Epidemiology and Community Health·A LanghammerL Bjermer
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
Nov 27, 2002·The European Respiratory Journal·J A HardieO Mørkve
Apr 2, 2005·The European Respiratory Journal·K StavemJ Erikssen
Jul 5, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Mar 21, 2009·Journal of Applied Physiology·Scott D KirktonPeter D Wagner
Oct 14, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Carlos O WeissLinda P Fried
Feb 6, 2010·Clinical Science·Nicholas S Hopkinson, Michael I Polkey
Oct 5, 2011·Health and Quality of Life Outcomes·Elena Gimeno-SantosUNKNOWN PROactive consortium
Jul 31, 2012·Archives of Physical Medicine and Rehabilitation·Remko SoerMichiel F Reneman
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Roberto C ChinDenis E O'Donnell
Dec 31, 2015·Respiratory Research·Erlend HasselSigurd Steinshamn
Nov 2, 2016·The European Respiratory Journal·Michael A RomanRichard Casaburi

❮ Previous
Next ❯

Citations

Nov 10, 2018·Beilstein Journal of Organic Chemistry·Carmen CurutiuAlina Maria Hoban
Oct 15, 2021·BMJ Open·Ragnhild Sørum FalkJan E Erikssen

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.