Abstract
Proinsulin levels as a marker of beta-cell dysfunction have not been described after clinical islet transplantation. Proinsulin secretion was studied in 23 type 1 diabetic patients after islet allotransplantation and in 20 age-matched nondiabetic controls. Fasting serum insulin, total proinsulin (TP), intact proinsulin, proinsulin fragments (PFs) and their ratios to insulin were determined 1 and 12 months after patients became insulin independent. TP, PF, and proinsulin/insulin ratios were lower in transplant recipients compared with controls, in patients who retained long-term insulin independence. Insulin, C-peptide, and intact proinsulin values were similar in transplant recipients and controls. Hormone levels remained stable over time in the group of patients who retained long-term insulin independence, but the TP and PF levels were higher at 12 months compared with 1 month in the group of patients who resumed insulin therapy. TP and PF levels were reduced in transplant recipients compared with controls but increased over time if insulin independence was lost.
References
Aug 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·F A LindgrenB E Persson
Oct 1, 1990·Diabetes·K OseiR M Ferguson
Jul 1, 1987·The Journal of Cell Biology·C J Rhodes, P A Halban
Jul 1, 1993·Diabetes·S E KahnD Porte
Jan 15, 1996·The Journal of Clinical Investigation·E R SeaquistR P Robertson
Apr 27, 1996·Transplantation·N M KnetemanD Finegood
Jul 1, 1997·Diabetologia·S M HaffnerM Stern
Nov 14, 1997·Diabetes·S E Kahn, P A Halban
Apr 9, 1998·Transplantation Proceedings·S A WhiteN J London
Sep 16, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·E ChristiansenS Madsbad
Nov 24, 1998·Metabolism: Clinical and Experimental·T BabazonoY Omori
Jul 27, 2000·The New England Journal of Medicine·A M ShapiroR V Rajotte
Mar 27, 2001·Transplantation Proceedings·S A WhiteA R Dennison
Feb 15, 2002·Diabetologia·F BertuzziA Secchi
Mar 21, 2002·Diabetes, Obesity & Metabolism·D K FuhrerH Jiang
Jun 28, 2002·Diabetes·Edmond A RyanA M James Shapiro
Citations
Jul 6, 2012·Current Diabetes Reports·Michael R Rickels
Oct 30, 2008·The Journal of Clinical Endocrinology and Metabolism·Michael R RickelsAli Naji
Jan 26, 2010·The Journal of Clinical Endocrinology and Metabolism·Michael R RickelsAli Naji
Aug 27, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A M KlimekC B Verchere
Mar 30, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M R Rickels, A Naji
Dec 13, 2018·Endocrine Reviews·Michael R Rickels, R Paul Robertson
Sep 9, 2017·Transplantation·Christian SchuetzUNKNOWN IPITA YIC Young Investigator Committee
Jun 29, 2021·Endocrine Reviews·Steven E KahnC Bruce Verchere