Cross-sectional associations of blood elements, clotting factors, nephropathy, and retinal outcomes in long duration type 1 diabetes.

Ophthalmic Epidemiology
Barbara E K KleinKristine E Lee

Abstract

To determine the association of blood elements, selected clotting factors, and nephropathy with proliferative diabetic retinopathy (PDR) and macular edema (ME) in those with long duration type 1 diabetes. Participants (N = 442) were seen in 2005-2007 at the 25-year follow-up of a population-based study of diabetic retinopathy, and were eligible for this analysis. Fundus photographs were graded using a standard retinopathy severity scheme. Laboratory measures included hematocrit, white blood cell and platelet counts, serum fibrinogen, interleukin-6, and von Willebrand factor. In models including duration of diabetes, hypertension, and diabetic nephropathy, only hematocrit was marginally associated with decreased odds of PDR (odds ratio 0.87; 95% confidence interval 0.74-1.01; P for trend per quintile = 0.06). Stratifying by nephropathy status, in those with and without nephropathy, there were no significant associations of any laboratory measures with PDR or ME. None of the variables we examined were associated with ME in individuals with or without nephropathy. In persons with long duration type 1 diabetes, none of the blood elements or clotting factors were associated with increased odds of PDR or ME. Investigation of common p...Continue Reading

References

Sep 1, 1986·Ophthalmology·R KleinM D Davis
Jan 1, 1988·Archives of Internal Medicine·R KleinD L DeMets
Jan 1, 1984·American Journal of Epidemiology·R KleinP S Voss
Jun 1, 1996·British Journal of Haematology·M VasseC Soria
Jul 27, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Martin M HartgeUlrich Kintscher
Dec 27, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lori D BashBrad C Astor
Mar 10, 2009·Microvascular Research·Rod D BraunAsad Abbas
Nov 11, 2009·Archives of Ophthalmology·Baqiyyah N ConwayTrevor J Orchard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

American Journal of Public Health
G CutterM Stromer
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Carlos M OliveiraJosé R Faria Abreu
© 2021 Meta ULC. All rights reserved