Cross-sectional comparison of point-of-care with laboratory HbA₁c in detecting diabetes in real-world remote Aboriginal settings

BMJ Open
Julia V MarleyDavid Atkinson

Abstract

To determine if point-of-care (POC) glycated haemoglobin (HbA₁c) is sufficiently accurate in real-world remote settings to predict or exclude the diagnosis of diabetes based on laboratory HbA1c measurements. Cross-sectional study comparing POC capillary HbA₁c results with corresponding venous HbA₁c levels measured in a reference laboratory. Aboriginal patients ≥15 years old who were due for diabetes screening at the participating clinics were invited to participate. Two hundred and fifty-five Aboriginal participants were enrolled and 241 were included in the analysis. 6 primary healthcare sites in the remote Kimberley region of Western Australia from September 2011 to November 2013. Concordance and mean differences between POC capillary blood HbA₁c measurement and laboratory measurement of venous blood HbA₁c level; POC capillary blood HbA1c equivalence value for screening for diabetes or a high risk of developing diabetes; sensitivity, specificity and positive-predictive value for diagnosing and screening for diabetes; barriers to conducting POC testing. Concordance between POC and laboratory results was good (ρ=0.88, p<0.001). The mean difference was -0.15% (95% limits of agreement, -0.67% to 0.36%). POC HbA₁c measurements ≥6....Continue Reading

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Citations

Feb 20, 2016·International Journal of Emergency Medicine·Fernando Gomez-PeraltaGuillermo E Umpierrez
Mar 18, 2016·Critical Reviews in Clinical Laboratory Sciences·Damien Gruson, Gabriel Ko
Feb 23, 2018·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Katherine CullineyUNKNOWN HUMBA Study Group
Feb 9, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Magdalena WalickaEdward Franek
Sep 23, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Jennifer A HirstAndrew J Farmer

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BETA
pharmacotherapy

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PathWest
Stata

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