PMID: 6971946May 15, 1981Paper

Cross-sectional study of a community with exceptional exposure to DDT

JAMA : the Journal of the American Medical Association
K KreissB T Jones

Abstract

The geometric mean level of total DDT in serum samples (76.2 ng/mL) from 499 persons living downstream from a defunct DDT-manufacturing plant was several times the national geometric mean (15.0 ng/mL). DDE isomers, metabolites of DDT, accounted for an average of 86.7% of total DDT. Total DDT levels increased with age, even when controlled for other independent variables also significantly associated with DDT: race, sex, fish consumption, years of residence, socioeconomic status, alcohol consumption, and serum triglyceride levels. Fish consumption, the second strongest determinant of DDT level, had one third the predictive power of age. Total DDT levels were not associated with specific illness or ill health. However, total DDT levels were positively associated with levels of serum cholesterol, triglyceride, and gamma-glutamyl transpeptidase. The finding that serum DDE levels increase with age suggests that no equilibrium in body burden has been reached or that pharmacokinetics or serum/adipose partition may vary with age.

Associated Clinical Trials

Citations

Feb 1, 1983·Environmental Health Perspectives·C W Heath
Feb 1, 1991·Environmental Health Perspectives·M A Kamrin, L J Fischer
May 1, 1985·Environmental Health Perspectives·K Kreiss
Oct 1, 1985·Environmental Health Perspectives·R Levine, D D Chitwood
Feb 1, 1983·Environmental Health Perspectives·R D Kimbrough
Feb 1, 1983·Environmental Health Perspectives·W Rogan, B Gladen
Mar 1, 1996·Environmental Health Perspectives·E Hodgson, P E Levi
Jun 1, 1997·Environmental Health Perspectives·W A Anwar
Aug 17, 1999·Occupational and Environmental Medicine·M SalaJ Grimalt
Dec 14, 2011·American Journal of Epidemiology·Henry Falk, Peter Briss
Aug 23, 2002·Toxicology Letters·O ChikuniJ U Skaare
Feb 7, 2006·Environmental Research·Xiaoyu HuangDavid O Carpenter
Jan 1, 1992·Archives of Environmental Contamination and Toxicology·A LommelO Wassermann
Mar 1, 1982·Environmental Monitoring and Assessment·R D Kimbrough
Mar 1, 1987·Bulletin of Environmental Contamination and Toxicology·S P SaxenaJ Chandra
May 1, 1989·Bulletin of Environmental Contamination and Toxicology·K K SteinbergD L Phillips
Jul 1, 1986·Archives of Environmental Contamination and Toxicology·B BushJ T Snow
Jul 1, 1989·Archives of Environmental Contamination and Toxicology·D L PhillipsL L Needham
May 1, 1982·Archives of Environmental Health·K KreissH E Humphrey

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