Cross-sectional study of a United Kingdom cohort of neonatal vein of galen malformation

Annals of Neurology
Francesca LecceV Ganesan

Abstract

Describe the course and outcomes in a UK national cohort of neonates with vein of Galen malformation identified before 28 days of life. Neonates with angiographically confirmed vein of Galen malformation presenting to 1 of 2 UK treatment centers (2006-2016) were included; those surviving were invited to participate in neurocognitive assessment. Results in each domain were dichotomized into "good" and "poor" categories. Cross-sectional and angiographic brain imaging studies were systematically interrogated. Logistic regression was used to explore potential outcome predictors. Of 85 children with neonatal vein of Galen malformation, 51 had survived. Thirty-four participated in neurocognitive assessment. Outcomes were approximately evenly split between "good" and "poor" categories across all domains, namely, neurological status, general cognition, neuromotor skills, adaptive behavior, and emotional and behavioral development. Important predictors of poor cognitive outcome were initial Bicêtre score ≤ 12 and presence of brain injury, specifically white matter injury, on initial imaging; in multivariate analysis, only Bicêtre score ≤ 12 remained significant. Despite modern supportive and endovascular treatment, more than one-third o...Continue Reading

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Citations

Dec 4, 2019·Developmental Medicine and Child Neurology·Vijeya Ganesan
May 28, 2019·Archives of Disease in Childhood·Stephanie MalarbiRod W Hunt
Nov 13, 2019·Developmental Medicine and Child Neurology·Hélène TaffinGuillaume Saliou
May 30, 2020·AJNR. American Journal of Neuroradiology·L ArkoD B Orbach
Jun 14, 2020·Developmental Medicine and Child Neurology·Boris Lubicz, Florence Christiaens
Nov 11, 2019·Neuroradiology·Kshitij MankadWinston Chong
Oct 3, 2020·NeoReviews·Erika G CordovaJudy A Estroff
Jan 30, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alice D'AmicoDanilo Buca
Feb 18, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Luis Fernando PulidoKemel A Ghotme
Apr 26, 2021·Pediatric Neurology·Francisco Brevis Nuñez, Christian Dohna-Schwake
Aug 24, 2021·Expert Review of Medical Devices·Panagiotis PrimikirisChristina Iosif

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