Cross-sectional study of CD4: CD8 ratio recovery in young adults with perinatally acquired HIV-1 infection

Medicine
Katrina M PollockSarah Fidler

Abstract

Antiretroviral therapy (ART) has improved survival into adulthood for young people with perinatally acquired HIV-1 (yp-PaHIV), but long-term prognosis remains unclear. We hypothesized that on-going immune activation, reflected in the failure of CD4:CD8 ratio normalization would be observed in yp-PaHIV, despite ART.A cross-sectional study of routinely collected clinical data from a cohort of yp-PaHIV (≥16 years).Data were collected from records of individuals attending a specialist clinic for yp-PaHIV transitioning to adult care. CD4:CD8 ratio and proportion with CD4:CD8 ratio ≥1, demographic data and viral parameters, including HIV-1 viral load (VL) and human cytomegalovirus (CMV) IgG, were analyzed with IBM SPSS Statistics v22.A total of 115 yp-PaHIV, median (IQR) age 22.0 (20.0-24.0) years, were studied, of whom 59 were females, and the majority were Black African 75/115 (65.2%). Where measured, CMV antibodies were frequently detected (71/74, 95.9%) and CMV IgG titre was inversely associated with CD4:CD8 ratio, (Rho -0.383, P = .012). Of those taking ART, 69 out of 90 (76.7%) yp-PaHIV had suppressed HIV viremia (<50 RNA copies/mL) and recovery of CD4:CD8 ratio to ≥1 was seen in 26 out of 69 (37.7%) with suppressed HIV viremia...Continue Reading

References

Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sine Reker HadrupAnders Wikby
Jan 18, 2007·Annals of Internal Medicine·Nicolai LohseNiels Obel
Oct 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elena LosinaKenneth A Freedberg
May 8, 2010·The Journal of Infectious Diseases·Jacqueline NeuhausJames D Neaton
Sep 17, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara LodiUNKNOWN CASCADE Collaboration in EuroCoord
Oct 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Giovanni GuaraldiFrank Palella
Jun 19, 2013·Immunological Reviews·Nichole R KlattSteven G Deeks
May 23, 2014·Current Infectious Disease Reports·Chia-Ching J WangDonald I Abrams
Jul 11, 2014·Current Opinion in HIV and AIDS·Joseph C Mudd, Michael M Lederman
Aug 28, 2014·Frontiers in Immunology·Maximilian MuenchhoffPhilip Jeremy Renshaw Goulder
Nov 14, 2014·Journal of the International AIDS Society·John ThornhillSarah Fidler
Aug 9, 2015·The Journal of Allergy and Clinical Immunology·Alan WinstonUNKNOWN UK Collaborative HIV Cohort Study
Sep 25, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael L FreemanMichael M Lederman
Oct 2, 2015·The Lancet. HIV·Sergio Serrano-Villar, Steven G Deeks
Apr 12, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Martina PenazzatoDorothy Mbori-Ngacha

❮ Previous
Next ❯

Citations

Mar 20, 2020·Journal of the Pediatric Infectious Diseases Society·Win Min HanThanyawee Puthanakit

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.