Cross-sectional Study of Glutamate in the Anterior Cingulate and Hippocampus in Schizophrenia

Schizophrenia Bulletin
Jürgen GallinatMartin Schaefer

Abstract

There has been growing support for dysfunctions of the excitatory glutamatergic system and its implications for the psychophysiology of schizophrenia. However, previous studies reported mixed results regarding glutamate concentrations in schizophrenia with varying deviations across brain regions. We used an optimized proton magnetic resonance spectroscopy procedure to measure absolute glutamate concentrations in the left hippocampal region and the anterior cingulate cortex (ACC) in 29 medicated patients with schizophrenia and in 29 control participants without mental disorder. The glutamate concentrations were significantly lower in the ACC but higher in the hippocampus of patients compared to controls. ACC and hippocampal glutamate concentrations correlated positively in patients but not in controls. ACC glutamate was weakly associated with Clinical Global Impression score and duration of illness in patients. Glutamate concentrations in schizophrenia deviate from controls and show associations with disease severity. A higher concentration of hippocampal glutamate in schizophrenia compared to controls is shown. The association between ACC and hippocampus glutamate concentrations in patients with schizophrenia suggests an abnorm...Continue Reading

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Citations

Feb 13, 2016·Der Nervenarzt·J GallinatG Leicht
Apr 5, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N A UranovaD D Orlovskaya
Jun 6, 2018·Frontiers in Psychology·Johanna BalzDaniel Senkowski
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Jun 14, 2016·Neural Plasticity·Christoph LindemannIleana L Hanganu-Opatz
Mar 11, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Min Tae M ParkLena Palaniyappan

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