Cross-sectional Study of Patients with Diffuse Large B-Cell Lymphoma: Assessing the Effect of Host Status, Tumor Burden, and Inflammatory Activity on Venous Thromboembolism

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Sung Hee LimSeok Jin Kim

Abstract

The risk factors for venous thromboembolism (VTE) in diffuse large B-cell lymphoma (DLBCL) are not clear although thrombosis can be associated with host status, tumor burden, and inflammatory activity. We assessed the effect of those factors on VTE in a cross-sectional study of patients enrolled in a prospective cohort study. We analyzed the occurrence of VTE in 322 patients with newly diagnosed DLBCL who received rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) between 2008 and 2011. Serum levels of inflammatory cytokines were measured from serum samples archived at diagnosis. With a median follow-up duration of 41.9 months, VTE was documented in 34 patients (10.6%). A comparison of baseline characteristics indicated the group with VTE had higher percentage of old age, stage III/IV and extranodal involvements than the group without VTE (p < 0.05). Thus, the International Prognostic Index was significantly associated with VTE, but the Khorana score was not. A univariate competing risk factor analysis for VTE revealed that increased levels of inflammatory cytokines such as interleukin (IL)-6 and IL-10 were also associated with VTE (p < 0.05) in addition to host and tumor burden. However, a multi...Continue Reading

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Citations

Jun 9, 2016·Leukemia & Lymphoma·Ina Hornemann BorgMarianne Tang Severinsen
Jul 6, 2016·Leukemia & Lymphoma·Kate L BurburyDavid A Westerman
Aug 6, 2016·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Patrizia FerroniFiorella Guadagni
Jul 10, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Ann S KimKeith R McCrae
Apr 2, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Akari Nishimura, Yoshiaki Ikeda
Oct 1, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hikmat Abdel-RazeqMais Zmaily

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