Cross-sectional study of reversible airway obstruction in LAM: better evidence is needed for bronchodilator and inhaled steroid use

Thorax
Jan Johnson, Simon R Johnson

Abstract

Lymphangioleiomyomatosis can be associated with reversible airflow obstruction and although no guidelines around reversibility testing or inhaled therapy exist, many patients receive bronchodilators and inhaled corticosteroids. To better identify those who may benefit, we examined bronchodilator reversibility and inhaled therapy in a national cohort of 213 subjects. 20% of those tested had airway reversibility by standard criteria. 55% of patients used 13 different combinations of bronchodilators and inhaled corticosteroids. Increasing inhaler classes were associated with reversibility and more rapid FEV1 decline. Reversibility testing should be performed in all patients and inhaled therapy should be formally studied.

References

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May 19, 2009·Chest·Angelo M Taveira-DaSilvaJoel Moss
Jan 2, 2010·The European Respiratory Journal·S R JohnsonUNKNOWN Review Panel of the ERS LAM Task Force
Mar 18, 2011·The New England Journal of Medicine·Francis X McCormackUNKNOWN MILES Trial Group
Nov 2, 2012·The Journal of Clinical Investigation·Elizabeth P Henske, Francis X McCormack
Mar 13, 2014·The Cochrane Database of Systematic Reviews·Kayleigh M Kew, Alieksei Seniukovich
Sep 23, 2014·The Lancet. Respiratory Medicine·Lydia FinneyPatrick Mallia
Aug 16, 2016·Clinics in Chest Medicine·Simon R JohnsonJoel Moss
Jan 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kang LeJoel Moss

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Citations

Dec 12, 2020·The European Respiratory Journal·Saisakul ChernbumroongSimon R Johnson
Apr 22, 2021·American Journal of Respiratory and Critical Care Medicine·Roya Babaei-JadidiSimon R Johnson
Aug 31, 2021·The Lancet. Respiratory Medicine·Cormac McCarthyFrancis X McCormack

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