PMID: 11918512Mar 29, 2002Paper

Cross-sensitivity between paroxetine and sertraline

The Annals of Pharmacotherapy
Caroline A Warnock, Abbas G Azadian

Abstract

To report a case of possible cross-sensitivity between selective serotonin-reuptake inhibitors (SSRIs). A 20-year-old Southeast Asian man developed a maculopapular rash soon after starting paroxetine. Following resolution of this rash, another skin reaction with the same distribution and appearance occurred after sertraline therapy was started. Cross-reactivity between drugs with similar structures has been reported; however, cross-reactivity among SSRI antidepressants is unexpected given their differences in chemical structure. The possibility of cross-reactivity between SSRI antidepressants should be considered by clinicians who wish to switch from one SSRI to another due to a dermatologic reaction.

References

Feb 1, 1982·British Journal of Clinical Pharmacology·U BustoE M Sellers
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Sep 1, 1996·The Journal of Allergy and Clinical Immunology·A MirandaC Juarez
Mar 10, 1998·The Journal of Clinical Psychiatry·C A ZarateA Madrid

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Citations

Aug 17, 2010·Indian Journal of Pharmacology·Praveen H KhairkarPrashant G Tiple
Jul 7, 2011·Photodermatology, Photoimmunology & Photomedicine·Laura Rodríguez-PazosJaime Toribio
Jul 25, 2006·Allergologia et immunopathologia·María T Soto MeraJosé F Filgueira Iglesias

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