Cross-Species Extrapolation of Uptake and Disposition of Neutral Organic Chemicals in Fish Using a Multispecies Physiologically-Based Toxicokinetic Model Framework

Environmental Science & Technology
Markus BrinkmannThomas G Preuss

Abstract

The potential to bioconcentrate is generally considered to be an unwanted property of a substance. Consequently, chemical legislation, including the European REACH regulations, requires the chemical industry to provide bioconcentration data for chemicals that are produced or imported at volumes exceeding 100 tons per annum or if there is a concern that a substance is persistent, bioaccumulative, and toxic. For the filling of the existing data gap for chemicals produced or imported at levels that are below this stipulated volume, without the need for additional animal experiments, physiologically-based toxicokinetic (PBTK) models can be used to predict whole-body and tissue concentrations of neutral organic chemicals in fish. PBTK models have been developed for many different fish species with promising results. In this study, we developed PBTK models for zebrafish (Danio rerio) and roach (Rutilus rutilus) and combined them with existing models for rainbow trout (Onchorhynchus mykiss), lake trout (Salvelinus namaycush), and fathead minnow (Pimephales promelas). The resulting multispecies model framework allows for cross-species extrapolation of the bioaccumulative potential of neutral organic compounds. Predictions were compared...Continue Reading

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Citations

May 17, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·John NicholsMichelle Embry
Feb 14, 2019·Environmental Toxicology and Chemistry·Ian Edhlund, Cindy Lee
Jul 17, 2018·Environmental Sciences Europe·Kristina RehbergerHelmut Segner
Dec 19, 2020·The Science of the Total Environment·Markus BrinkmannHenner Hollert
Jun 25, 2021·Environmental Science & Technology·Annika Mangold-DöringMarkus Brinkmann
Jul 31, 2021·The Science of the Total Environment·Lara M SchuijtPaul J Van den Brink
Jul 21, 2021·Journal of Hazardous Materials·Gulsah DogruerJason P van de Merwe

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