Cross-species functional diversity within the PIN auxin efflux protein family

ELife
Devin L O'ConnorOttoline Leyser

Abstract

In Arabidopsis, development during flowering is coordinated by transport of the hormone auxin mediated by polar-localized PIN-FORMED1 (AtPIN1). However Arabidopsis has lost a PIN clade sister to AtPIN1, Sister-of-PIN1 (SoPIN1), which is conserved in flowering plants. We previously proposed that the AtPIN1 organ initiation and vein patterning functions are split between the SoPIN1 and PIN1 clades in grasses. Here we show that in the grass Brachypodium sopin1 mutants have organ initiation defects similar to Arabidopsis atpin1, while loss of PIN1 function in Brachypodium has little effect on organ initiation but alters stem growth. Heterologous expression of Brachypodium SoPIN1 and PIN1b in Arabidopsis provides further evidence of functional specificity. SoPIN1 but not PIN1b can mediate flower formation in null atpin1 mutants, although both can complement a missense allele. The behavior of SoPIN1 and PIN1b in Arabidopsis illustrates how membrane and tissue-level accumulation, transport activity, and interaction contribute to PIN functional specificity.

References

Aug 15, 2018·The New Phytologist·Phillip A ConklinMichael J Scanlon
Sep 13, 2018·Annual Review of Genetics·Olga V SedelnikovaJane A Langdale
Dec 27, 2018·Plants·Annis E Richardson, Sarah Hake
Jun 12, 2019·The Plant Journal : for Cell and Molecular Biology·Jill C PrestonJinshun Zhong
Jul 28, 2019·The Plant Journal : for Cell and Molecular Biology·Karel MüllerJan Petrášek
Oct 2, 2019·The Plant Journal : for Cell and Molecular Biology·Tiago D G NunesMichael T Raissig
Mar 8, 2018·International Journal of Molecular Sciences·Alexander BetekhtinRobert Hasterok
Feb 14, 2018·Development·Neha Bhatia, Marcus G Heisler
Jul 12, 2018·Plant Cell Reports·Magdalena Biedroń, Alicja Banasiak
Feb 9, 2020·International Journal of Molecular Sciences·Alexander BetekhtinRobert Hasterok

Citations

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·I MooreKlaus Palme
Nov 26, 1999·The Plant Journal : for Cell and Molecular Biology·A SessionsM F Yanofsky
Apr 13, 2000·The Plant Cell·D ReinhardtCris Kuhlemeier
Nov 25, 2003·Nature·Didier ReinhardtCris Kuhlemeier
Apr 9, 2005·Trends in Plant Science·Ivan A PaponovKlaus Palme
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Henrik JönssonEric Mjolsness
Jan 21, 2006·Science·Jian XuBen Scheres
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Richard SmithPrzemyslaw Prusinkiewicz
Mar 21, 2006·Current Biology : CB·Tom BennettOttoline Leyser
Apr 8, 2006·Science·Justyna WiśniewskaJirí Friml
Apr 19, 2006·Genes & Development·Enrico ScarpellaThomas Berleth
Jun 7, 2006·Current Biology : CB·Ottoline Leyser
Oct 18, 2006·Genes & Development·Michael SauerEva Benková
Sep 11, 2007·Development·Sean P GordonElliot M Meyerowitz
Apr 9, 2008·Current Biology : CB·Jürgen Kleine-VehnJirí Friml
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jürgen Kleine-VehnJirí Friml
Feb 11, 2009·Genes & Development·Emmanuelle M BayerCris Kuhlemeier
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Przemyslaw PrusinkiewiczOttoline Leyser
Jun 29, 2010·Journal of Experimental Botany·Anne Sophie KnöllerAngus S Murphy
Oct 6, 2010·Plant Physiology·Ottoline Leyser
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gemma D BilsboroughMiltos Tsiantis
Jun 23, 2012·Plant Physiology·Bernadette GuenotCris Kuhlemeier
Jan 29, 2013·Plant Physiology·Paul Derbyshire, Mary E Byrne
Feb 26, 2013·PLoS Genetics·Megan G SawchukEnrico Scarpella
Sep 4, 2013·Cell Research·Jin MiaoLi-Jia Qu
Oct 5, 2013·Developmental Cell·Daniel KierzkowskiCris Kuhlemeier
Jun 1, 1974·Planta·P H Rubery, A R Sheldrake
Jan 28, 2014·Nature Biotechnology·Yanfang FuJ Keith Joung
Feb 7, 2014·PLoS Computational Biology·Devin L O'ConnorSarah Hake
Apr 25, 2014·Molecular Biology and Evolution·Tom BennettC Jill Harrison

Related Concepts

PIN1 gene
Protein Family
Membrane
Arabidopsis
PIN1
Entire Vein
Auxins
Transcription Initiation
Mutant Proteins
Organ

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

© 2020 Meta ULC. All rights reserved