Cross-talk between bacterial pathogens and their host cells

Annual Review of Cell and Developmental Biology
J E Galán, J B Bliska

Abstract

A taxonomically diverse group of bacterial pathogens have evolved a variety of strategies to subvert host-cellular functions to their advantage. This often involves two-way biochemical interactions leading to responses in both the pathogen and host cell. Central to this interaction is the function of a specialized protein secretion system that directs the export and/or translocation into the host cells of a number of bacterial proteins that can induce or interfere with host-cell signal transduction pathways. The understanding of these bacterial/host-cell interactions will not only lead to novel therapeutic approaches but will also result in a better understanding of a variety of basic aspects of cell physiology and immunology.

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Citations

Jul 9, 1999·Progress in Lipid Research·C C DiRussoJ D Weimar
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Methods Mentioned

BETA
GTPases

Software Mentioned

InvJ
Spa32

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