Cross Talk between Chemosensory Pathways That Modulate Chemotaxis and Biofilm Formation

MBio
Zhou HuangShuang-Jiang Liu

Abstract

Complex chemosensory systems control multiple biological functions in bacteria, such as chemotaxis, gene regulation, and cell cycle progression. Many species contain more than one chemosensory system per genome, but little is known about their potential interplay. In this study, we reveal cross talk between two chemosensory pathways that modulate chemotaxis and biofilm formation in Comamonas testosteroni We demonstrate that some chemoreceptors that govern chemotaxis also contribute to biofilm formation and these chemoreceptors can physically interact with components of both pathways. Finally, we show that the chemotaxis histidine kinase CheA can phosphorylate not only its cognate response regulator CheY2 but also one of the response regulators from the pathway mediating biofilm formation, FlmD. The phosphoryl group transfer from CheA to CheY2 is much faster than that from CheA to FlmD, which is consistent with chemotaxis being a fast response and biofilm formation being a much slower developmental process. We propose that cross talk between chemosensory pathways may play a role in coordination of complex behaviors in bacteria.IMPORTANCE In many bacteria, two or more homologous chemosensory pathways control several cellular func...Continue Reading

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Citations

Jun 5, 2019·International Journal of Molecular Sciences·Yun-Hao WangShuang-Jiang Liu
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Stuti K Desai, Linda J Kenney
Apr 25, 2020·Environmental Microbiology·Yun-Hao WangShuang-Jiang Liu
Sep 2, 2019·Trends in Microbiology·Wen Yang, Ariane Briegel
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Jan 15, 2021·Microbiology and Molecular Biology Reviews : MMBR·Miguel A MatillaTino Krell
Jan 17, 2021·Applied and Environmental Microbiology·Hai-Zhen ZhuShuang-Jiang Liu
Mar 9, 2021·Current Opinion in Microbiology·Vadim M GumerovIgor B Zhulin
May 11, 2021·Frontiers in Microbiology·Elena E GanusovaGladys Alexandre
Jan 22, 2022·Environmental Science and Pollution Research International·Muhammad IbrarXuewei Yang

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Methods Mentioned

BETA
two-hybrid
motility assay
Bioscreen

Software Mentioned

CDvist
MAFFT
Quantity One
HMMER
COMSTAT

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