Abstract
Nonvascular smooth muscle, such as the iris sphincter, receives double reciprocal innervation: stimulation of the parasympathetic nervous system (cholinergic muscarinic), which functions through the polyphosphoinositide (PPI) signaling pathway, contracts it, while activation of the sympathetic nervous system (beta-adrenergic), which functions through the cAMP system, relaxes it. Interactions between the two second messenger systems are important in regulation of smooth muscle tone and represent an important focal point for pharmacological manipulation. Here, I have summarized the experimental evidence in support of the hypothesis that the cross talk between cAMP and the PPI cascade could constitute a biochemical correlate for this functional antagonism. Recent studies suggest that cAMP inhibition is on Ca2+ mobilization rather than myosin light chain phosphorylation. Thus, cAMP-elevating agents, which inhibit agonist-induced PPI hydrolysis, are effective relaxants. Furthermore, inositol 1,4,5-trisphosphate (IP3) appears to be involved in both Ca2+ release from the sarcoplasmic reticulum and in Ca2+ influx through the plasma membrane, and since a reduction in intracellular Ca2+ ([Ca2+]i) is the underlying mechanism for cAMP-medi...Continue Reading
Citations
Feb 1, 1997·Endocrine·A M AzzaroloD W Warren
Oct 26, 2000·European Journal of Pharmacology·S Y YousufzaiA A Abdel-Latif
Dec 16, 1998·European Journal of Pharmacology·S Y Yousufzai, A A Abdel-Latif
Feb 23, 1999·Life Sciences·K H DingA A Abdel-Latif
Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·Alejandra RojasEdgar P Heimer-de la Cotera
Oct 6, 1997·Cellular Signalling·K H DingA A Abdel-Latif
Feb 27, 1999·Cellular Signalling·K H DingA A Abdel-Latif
Oct 26, 1999·Cellular Signalling·C M YangL W Fan
Jul 6, 2000·European Journal of Biochemistry·A VoglI Boekhoff
Sep 2, 1999·Critical Care Medicine·S AkhtarJ P Kampine
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Tertyshnikova, A Fein
Mar 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·S L Carrithers
Nov 17, 2009·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Isao Matsuoka, Masaaki Ito
Apr 2, 1998·Current Eye Research·S Y Yousufzai, A A Abdel-Latif
Oct 25, 1996·Biochemical Pharmacology·G K MaratheA A Abdel-Latif
Sep 1, 2004·Lancet·Stephen I Rennard
Mar 7, 2001·Biochemical Pharmacology·T Schlüter, R Bohnensack
Mar 1, 2006·Respiratory Research·Yan Bai, Michael J Sanderson
Mar 23, 2005·Experimental Eye Research·David J CollisonJulie Sanderson
Jul 13, 2004·Biochimica Et Biophysica Acta·Alan K Howe
Mar 5, 2011·European Journal of Pharmacology·Sara BaldassanoFlavia Mulè
Nov 3, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patricia Campos-BedollaLuis M Montaño
Jan 1, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Cornelia E van MeijerenDick J de Wildt
Sep 9, 2004·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eri NakamuraHikaru Suzuki
Feb 27, 1999·Endocrine Reviews·J J Evans
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Eric V Leaver, Pamela A Pappone
Jan 7, 2000·Eye·G W NietgenM E Durieux
May 22, 2001·Experimental Biology and Medicine·A A Abdel-Latif
Oct 3, 1998·Neuroscience·G ChidlowN N Osborne