Cross talk between engulfment receptors stabilin-2 and integrin αvβ5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes.

Molecular and Cellular Biology
Soyoun KimIn-San Kim

Abstract

Efficient cell corpse clearance is critical for health in organisms. Apoptotic cells displaying phosphatidylserine (PS) are recognized by engulfment receptors and ingested through two conserved pathways. In one pathway, engulfment receptor brain-specific angiogenesis inhibitor 1 (BAI-1) or integrin functions upstream of ELMO/DOCK180 and activate the small GTPase Rac1. In the other pathway, engulfment receptor CED-1 or stabilin-2 acts in concert with the adaptor protein GULP to activate Rac1. Stabilin-2, a PS receptor, facilitates phagocytosis of apoptotic cells and mediates the production of anti-inflammatory cytokines. Here, we propose that the stabilin-2 extracellular domain consisting of integrin-binding fasciclin 1 (FAS1) domains coordinates the activities of the two phagocytic pathways via direct interactions with integrin. Interactions between stabilin-2 and integrin were determined using biochemical assays, including coimmunoprecipitation and fluorescence resonance energy transfer (FRET). These interactions appear to have functional relevance, since knockdown of endogenous αvβ5 expression or treatment with a function-blocking αvβ5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble...Continue Reading

References

Jul 1, 1968·Experimental Cell Research·I Gigli, R A Nelson
Mar 4, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·H ImachiJ Takahara
Oct 26, 2000·Nature·J Savill, V Fadok
May 11, 2001·Nature·R S ScottG K Matsushima
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·P M HensonV A Fadok
May 10, 2002·Nature·Rikinari HanayamaShigekazu Nagata
Jun 29, 2002·Experimental & Molecular Medicine·Cheong Weon ChoDo Young Yoon
Aug 11, 2004·The Journal of Experimental Medicine·Kenichi AsanoMasato Tanaka
May 17, 2005·Immunity·Lynda M Stuart, R Alan B Ezekowitz
Dec 22, 2005·Nature Immunology·Peter M Henson
Jun 27, 2007·Journal of Cell Science·Jason M Kinchen, Kodi S Ravichandran
Oct 26, 2007·Nature·Masanori MiyanishiShigekazu Nagata
Oct 27, 2007·Cell Death and Differentiation·S-Y ParkI-S Kim
Jan 24, 2008·Current Biology : CB·Donna L Bratton, Peter M Henson
Jan 31, 2008·The Journal of Biological Chemistry·Seung-Yoon ParkIn-San Kim
May 22, 2008·Journal of Cell Science·Aurélien G Dupuy, Emmanuelle Caron
Nov 5, 2008·The Journal of Veterinary Medical Science·Dong-Choon AhnIn-Shik Kim
Feb 17, 2009·Current Biology : CB·Daeho ParkKodi S Ravichandran
Mar 31, 2009·FEBS Letters·Seung-Yoon ParkIn-San Kim
Mar 17, 2010·Current Biology : CB·Tsung-Yuan Hsu, Yi-Chun Wu
May 1, 2010·Nature Reviews. Rheumatology·Luis E MuñozMartin Herrmann
May 13, 2010·Apoptosis : an International Journal on Programmed Cell Death·Jason M Kinchen
Jun 17, 2010·Apoptosis : an International Journal on Programmed Cell Death·Edward B Thorp
Jun 30, 2010·The Journal of Cell Biology·Michael R Elliott, Kodi S Ravichandran
Sep 2, 2010·The Journal of Experimental Medicine·Kodi S Ravichandran
Mar 26, 2011·The American Journal of Pathology·Jennifer D Sokolowski, James W Mandell
Nov 1, 2011·Molecular and Cellular Biology·Satoshi TodaShigekazu Nagata

❮ Previous
Next ❯

Citations

Feb 19, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Seung-Yoon Park, In-San Kim
Dec 15, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Raasay S JonesMarina A Lynch
Jun 12, 2013·Molecular and Cellular Biology·Boris ShklyarEstee Kurant
Jul 4, 2013·Investigative Ophthalmology & Visual Science·Debjani GagenDonna M Peters
Mar 14, 2014·Molecular Biology of the Cell·Ronald S FlannaganSergio Grinstein
Apr 18, 2015·International Journal of Cell Biology·Madhu S PandeyPaul H Weigel
May 13, 2017·Experimental & Molecular Medicine·Seung-Yoon Park, In-San Kim
May 10, 2017·The Plant Journal : for Cell and Molecular Biology·Hui XueGeorg J Seifert
May 27, 2015·Cells·Izma Abdul ZaniSreenivasan Ponnambalam
Dec 20, 2017·Frontiers in Immunology·Nicole D BarthIan Dransfield
Jul 4, 2018·Acta Crystallographica. Section D, Structural Biology·Aleksandra Twarda-ClapaTad A Holak
Feb 12, 2014·Molecular and Cellular Biology·Chihiro NishiShigekazu Nagata
May 16, 2014·American Journal of Physiology. Renal Physiology·Rushi GandhiLakshman Gunaratnam
Dec 20, 2015·Immunological Reviews·Kristen K Penberthy, Kodi S Ravichandran
May 21, 2020·International Journal of Molecular Sciences·Edward N Harris, Erika Baker
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·C CasariC V Denis
Jul 23, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Cyrill GéraudSergij Goerdt
Mar 24, 2018·Frontiers in Immunology·Evgeny ShlyakhoverEstee Kurant
Aug 23, 2019·Biomolecules·Seung-Yoon Park, In-San Kim
Jul 21, 2017·Scientific Reports·Inês B SantarinoOtília V Vieira
Oct 28, 2018·Nature Communications·Noumeira HamoudJean-François Côté
Oct 17, 2019·Molecular Neurobiology·Steven A RobicsekSylvain Doré
Mar 13, 2014·Physiological Genomics·Alexander B Bloom, Muhammad H Zaman
Apr 26, 2019·Nature Reviews. Immunology·Greg Lemke
May 1, 2021·Cells·Jana Krystofova Mike, Donna Marie Ferriero
May 8, 2013·Developmental and Comparative Immunology·Claire B Péan, Marc S Dionne
Jul 20, 2021·Seminars in Immunopathology·Lidia Bosurgi, Carla V Rothlin
Aug 28, 2021·International Journal of Molecular Sciences·Szilvia LukácsiKrisztina Takács-Vellai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.