Cross-talk between fetal membranes and visceral adipose tissue involves HMGB1-RAGE and VIP-VPAC2 pathways in human gestational diabetes mellitus

Acta Diabetologica
Carmela SantangeloSusanna Morano

Abstract

Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy. Maternal adipose tissue and fetal membranes secrete various molecules that are relevant players in the pathogenesis of GDM. This pilot study aimed to examine whether the expression of the high mobility group box 1 protein (HMGB1) and its receptor for advanced glycation end products (RAGE), and the vasoactive intestinal peptide (VIP) and its receptors (VPAC-1,-2) were modified in pregnant women with GDM. Fetal membranes (FMs), omental adipose tissue (VAT) explants, and serum samples were obtained from 12 women with GDM and 12 with normal glucose tolerance (NGT) at delivery. The expression of HMGB1, RAGE and VIP, VPAC-1,-2 was detected by Western Blotting in explants; circulating levels and "in vitro" release of HMGB1 and VIP were measured by ELISA tests. HMGB1 tissue expression was higher in FMs obtained from GDM women (p = 0.02) than in FMs from NGT women. VPAC2 (p = 0.03) and RAGE (p = 0.03) tissue expressions were significantly increased in VAT from GDM subjects. Only FMs of NGT released detectable levels of HMGB1, which was not observed in samples obtained from GDM. VAT of GDM released lower levels of VIP (p = 0.05...Continue Reading

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Citations

Jun 10, 2020·International Journal of Molecular Sciences·Tiziana FilardiElisabetta Ferretti
Aug 28, 2020·American Journal of Reproductive Immunology : AJRI·Chelsea A Saito ReisClaire E Kendal-Wright
Jan 17, 2020·International Journal of Molecular Sciences·Rebecca C RancourtAndreas Plagemann
Dec 19, 2020·International Journal of Environmental Research and Public Health·Amira Mohammed Ali, Hiroshi Kunugi
Oct 29, 2020·Journal of Endocrinological Investigation·G CatanzaroE Ferretti
Jun 17, 2021·European Journal of Clinical Nutrition·Cara TrivettDilys J Freeman
Jul 25, 2021·International Journal of Molecular Sciences·Dominik Franciszek DłuskiMaciej Skrzypczak

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