Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells.

Molecular Biology of the Cell
Bruce A BoswellL S Musil

Abstract

Homeostasis in the lens is dependent on an extensive network of cell-to-cell gap junctional channels. Gap junction-mediated intercellular coupling (GJIC) is higher in the equatorial region of the lens than at either pole, an asymmetry believed essential for lens transparency. Primary cultures of embryonic chick lens epithelial cells up-regulate GJIC in response to purified fibroblast growth factor (FGF)1/2 or to medium conditioned by vitreous bodies, the major reservoir of factors (including FGF) for the lens equator. We show that purified bone morphogenetic protein (BMP)2, -4, and -7 also up-regulate GJIC in these cultures. BMP2, -4, or both are present in vitreous body conditioned medium, and BMP4 and -7 are endogenously expressed by lens cells. Remarkably, lens-derived BMP signaling is required for up-regulation of GJIC by purified FGF, and sufficient for up-regulation by vitreous humor. This is the first demonstration of an obligatory interaction between FGF and BMPs in postplacode lens cells, and of a role for FGF/BMP cross-talk in regulating GJIC in any cell type. Our results support a model in which the angular gradient in GJIC in the lens, and thus proper lens function, is dependent on signaling between the FGF and BMP ...Continue Reading

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Citations

Aug 31, 2011·Molecular Genetics and Genomics : MGG·Mark Charlton-PerkinsTiffany A Cook
Mar 27, 2009·Molecular Biology of the Cell·Teresa I ShakespeareThomas W White
Apr 2, 2010·Molecular Biology of the Cell·Bruce A BoswellLinda S Musil
Jun 22, 2012·Molecular Biology of the Cell·Miguel JarrinLena Gunhaga
Mar 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ralf DahmGijs F J M Vrensen
Mar 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F J LovicuR U de Iongh
Nov 26, 2013·The Journal of Clinical Investigation·Caterina SellittoThomas W White
May 19, 2010·Cellular and Molecular Life Sciences : CMLS·Simone BraigAnja-Katrin Bosserhoff
Aug 13, 2009·Expert Review of Anticancer Therapy·Athanassios KyrgidisKostantinos Antoniades
Oct 5, 2010·The International Journal of Biochemistry & Cell Biology·G Martinez, R U de Iongh
Dec 24, 2008·Experimental Eye Research·Bruce A BoswellLinda S Musil
May 6, 2015·Experimental Eye Research·Ian Michael Wormstone, Julie Ann Eldred
Jun 5, 2012·Developmental Biology·Xiaohong SongKunimasa Ohta
Dec 3, 2010·PLoS Pathogens·Tamas DolowschiakMathias W Hornef
Sep 7, 2016·Differentiation; Research in Biological Diversity·Mallika PathaniaMelinda K Duncan
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Jan 6, 2012·Molecular BioSystems·Kurt A SchalperJuan C Sáez
Mar 29, 2014·Development, Growth & Differentiation·Xiaohong SongKunimasa Ohta
Sep 19, 2019·Investigative Ophthalmology & Visual Science·Virginijus ValiunasThomas W White
Sep 26, 2020·International Journal of Molecular Sciences·Peter R BrinkThomas W White

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