Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases

Metallomics : Integrated Biometal Science
M KawaharaK Tanaka

Abstract

Increasing evidence suggests that disruption of metal homeostasis contributes to the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, prion diseases, Lewy body diseases, and vascular dementia. Conformational changes of disease-related proteins (amyloidogenic proteins), such as β-amyloid protein, prion proteins, and α-synuclein, are well-established contributors to neurotoxicity and to the pathogenesis of these diseases. Recent studies have demonstrated that these amyloidogenic proteins are metalloproteins that bind trace elements, including zinc, iron, copper, and manganese, and play significant roles in the maintenance of metal homeostasis. We present a current review of the role of trace elements in the functions and toxicity of amyloidogenic proteins, and propose a hypothesis integrating metal homeostasis and the pathogenesis of neurodegenerative diseases that is focused on the interactions among metals and between metals and amyloidogenic proteins at the synapse, considering that these amyloidogenic proteins and metals are co-localized at the synapse.

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Citations

Feb 1, 2018·Nutrients·Masahiro KawaharaMidori Kato-Negishi
Oct 1, 2018·The European Journal of Neuroscience·Yukihiro Yamada, Rebecca A Prosser
Feb 6, 2020·Biomolecules·Marco Bisaglia, Luigi Bubacco
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Sep 27, 2018·Frontiers in Neuroscience·Jun-Lin LiuChuang Guo
Aug 22, 2018·International Journal of Molecular Sciences·Yutaka Sadakane, Masahiro Kawahara
Apr 11, 2020·International Journal of Molecular Sciences·Masahiro KawaharaKen-Ichiro Tanaka
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Nov 26, 2020·Metallomics : Integrated Biometal Science·Jemmyson Romário de Jesus, Marco Aurélio Zezzi Arruda
Nov 21, 2020·International Journal of Molecular Sciences·Yan ZhangLin Zheng
Feb 3, 2021·International Journal of Molecular Sciences·Masahiro KawaharaKen-Ichiro Tanaka
May 1, 2021·Metallomics : Integrated Biometal Science·Jorge Moreda-PiñeiroPilar Bermejo-Barrera
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