Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism

Molecular Endocrinology
L I McKay, J A Cidlowski

Abstract

Nuclear factor kappa B (NF-kappa B) is an inducible transcription factor that positively regulates the expression of proimmune and proinflammatory genes, while glucocorticoids are potent suppressors of immune and inflammatory responses. NF-kappa B and the glucocorticoid receptor (GR) physically interact, resulting in repression of NF-kappa B transactivation. In transient cotransfection experiments, we demonstrate a dose-dependent, mutual antagonism between NF-kappa B and GR. Functional dissection of the NF-kappa B p50 and p65 subunits and deletion mutants of GR indicate that the GR antagonism is specific to the p65 subunit of NF-kappa B heterodimer, whereas multiple domains of GR are essential to repress p65-mediated transactivation. Despite its repression of GR transactivation, p65 failed to block the transrepressive GR homologous down-regulation function. We also demonstrate that negative interactions between p65 and GR are not selective for GR, but also occur between NF-kappa B and androgen, progesterone B, and estrogen receptors. However, although each of these members of the steroid hormone receptor family is repressed by NF-kappa B, only GR effectively inhibits p65 transactivation. Further, in cotransfections using a chim...Continue Reading

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W D TilleyM J McPhaul
Aug 29, 1986·Cell·V GiguèreR M Evans
Mar 1, 1985·Somatic Cell and Molecular Genetics·K HidakaL Siminovitch
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·I AlkalayY Ben-Neriah
Nov 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·C M JewellJ A Cidlowski
Dec 1, 1995·The Journal of Experimental Medicine·I M AdcockP J Barnes
Nov 15, 1995·Genes & Development·I M VermaS Miyamoto
Feb 17, 1995·The Journal of Biological Chemistry·R LinJ Hiscott
Mar 30, 1995·The New England Journal of Medicine·P J Barnes
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Ray, K E Prefontaine
Mar 15, 1996·The Journal of Biological Chemistry·E KalkhovenB van der Burg
Jan 1, 1996·Annual Review of Immunology·A S Baldwin

❮ Previous
Next ❯

Citations

Mar 3, 2011·Current Rheumatology Reports·Debby den UylWillem F Lems
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Katy A MuzikarPeter B Dervan
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·C E PierreuxF P Lemaigre
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·C Z SongT D Gelehrter
Apr 5, 2005·The Plant Cell·Stefan de FolterGerco C Angenent
Jul 15, 2003·Journal of Virology·Helen J BrownRen Sun
Jul 4, 2012·Molecular and Cellular Biology·Bryce VincentZhengxin Wang
May 30, 2003·Molecular and Cellular Biology·Matthew R YudtJohn A Cidlowski
May 15, 2004·Molecular and Cellular Biology·Marcela A HermosoJohn A Cidlowski
Jul 30, 2004·Molecular and Cellular Biology·Tobias CarlingShi Huang
Apr 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bit Na KangMathur S Kannan
Dec 19, 2013·Clinical & Developmental Immunology·Teresa SchaumannAndreas Jäger
Sep 16, 2006·American Journal of Respiratory and Critical Care Medicine·Maisa JaradatAnton M Jetten
Oct 20, 2007·American Journal of Respiratory Cell and Molecular Biology·Omar TlibaYassine Amrani
Aug 10, 2000·The Journal of Clinical Investigation·T NagayaH Seo
Mar 18, 2008·Respiratory Research·Krishnaswamy G TirumurugaanMathur S Kannan
Oct 7, 2005·Arthritis Research & Therapy·Maurizio CutoloBarbara Villaggio
Dec 31, 2010·Endocrinology·Adam HinzeyJeanette I Webster Marketon
May 31, 2007·The Journal of Clinical Endocrinology and Metabolism·Christine M Jewell, John A Cidlowski
Oct 22, 2010·Molecular Endocrinology·Neeraja DharmarajDaniel D Carson
Jun 1, 2010·Toxins·Jeanette I Webster Marketon, Esther M Sternberg
Feb 1, 2000·Biochemical and Biophysical Research Communications·T PelzerL Neyses
Aug 2, 2001·Biochemical and Biophysical Research Communications·H J LeeC Chang
Feb 11, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ankur JainAbbot F Clark
Mar 5, 1999·Molecular Neurobiology·C L BetheaZ N Lu
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·S R Price
Nov 26, 2005·Expert Opinion on Investigational Drugs·Jeffrey N MinerAndrés Negro-Vilar
Jan 28, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M PascussiP Maurel
Dec 25, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Adriana Maggi, Alessandro Villa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.