Abstract
Neuron-astrocyte interactions play a crucial role during development and in the adult brain. During development, glial cells are involved in the guidance of neuronal precursors and in extending neuronal fiber projections. Astrocytes can promote neurite outgrowth, both "in vitro" and "in vivo". In the central nervous system (CNS), they express receptors for a variety of growth factors (GFs), neurotransmitters and/or neuromodulators. In turn, neuronal cells can respond to astrocyte-derived growth factors and control astrocyte function via a common set of signaling molecules and intracellular transducing pathways. It is also well established that astrocytes are involved with regenerative failure within the CNS following injury. Increasing evidence support the viewpoint that soluble factors from lymphoid/mononuclear cells modulate the growth and function of cells found in the CNS, specifically macroglia and microglia cells. Furthermore, glial cells can secrete immunoregulatory molecules that influence immune cells, as well as the glial cells themselves. In recent years, a bi-directional flow of informational molecules between LHRH neurons, subserving the neuroendocrine control of reproductive function, and astroglia cells has been ...Continue Reading
Citations
Jul 1, 2017·Frontiers in Pharmacology·Simona AdessoStefania Marzocco
Apr 1, 2020·Frontiers in Aging Neuroscience·Maria Francesca SerapideBianca Marchetti
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R CiccarelliP Di Iorio
Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R AvolaB Marchetti
Dec 15, 2007·Journal of Pineal Research·Emanuela EspositoSalvatore Cuzzocrea
Oct 20, 2018·Journal of Clinical Medicine·Simona AdessoStefania Marzocco
Feb 10, 2009·The European Journal of Neuroscience·N SalmasoB Woodside
Aug 12, 2009·Journal of Biological Physics·L BilleciA Ahluwalia
Sep 20, 2020·Biomolecules·Loredana LeggioNunzio Iraci
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
May 22, 2007·Biochemical Society Transactions·M SvenssonP E Andrén
Apr 5, 2007·Neurochemical Research·Poincyane Assis-NascimentoLaura M Mudd
Nov 12, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Emanuela EspositoSalvatore Cuzzocrea
Nov 23, 2013·Biomolecules & Therapeutics·Jung Nam KimKyoung Ja Kwon
May 20, 2000·Synapse·F GalloB Marchetti
Jun 25, 2020·Journal of Clinical Medicine·Bianca MarchettiNunzio Iraci
Sep 30, 2000·Journal of Neuroendocrinology·F GalloB Marchetti
Oct 7, 2015·Frontiers in Psychiatry·Carmem GottfriedWilson Savino
Jul 6, 2010·Neurochemistry International·Stefania MarzoccoGiuseppina Autore