Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus

FEMS Microbiology Letters
Thomas DrepperBernd Masepohl

Abstract

Rhodobacter capsulatus NtrB/NtrC two-component regulatory system controls expression of genes involved in nitrogen metabolism including urease and nitrogen fixation genes. The ntrY-ntrX genes, which are located immediately downstream of the nifR3-ntrB-ntrC operon, code for a two-component system of unknown function. Transcription of ntrY starts within the ntrC-ntrY intergenic region as shown by primer extension analysis, but maximal transcription requires, in addition, the promoter of the nifR3-ntrB-ntrC operon. While ntrB and ntrY single mutant strains were able to grow with either urea or N2 as sole nitrogen source, a ntrB/ntrY double mutant (like a ntrC-deficient strain) was no longer able to use urea or N2. These findings suggest that the histidine kinases NtrB and NtrY can substitute for each other as phosphodonors towards the response regulator NtrC.

References

Oct 1, 1994·Journal of Bacteriology·D Foster-HartnettR G Kranz
May 1, 1993·Journal of Bacteriology·W R McClearyA J Ninfa
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·D P ZimmerS Kustu
Apr 3, 2001·Current Opinion in Microbiology·H Xu, T R Hoover
Jan 10, 2002·Microbiology·Daniël T VerhammeKlaas J Hellingwerf
Jun 5, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M L IshidaF O Pedrosa
Nov 4, 2004·The Journal of Biological Chemistry·Kaneyoshi YamamotoAkira Ishihama

❮ Previous
Next ❯

Citations

Dec 14, 2007·Annual Review of Genetics·Michael T Laub, Mark Goulian
Jul 7, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Corinna RademacherBernd Masepohl
Dec 23, 2011·Molecular Microbiology·Abhijit SarkarBarbara Reinhold-Hurek
May 16, 2012·Molecular Microbiology·Mariela del Carmen CarricaFernando Alberto Goldbaum
Feb 20, 2007·Protein Expression and Purification·Marcelo Constantino AssumpçãoElaine Machado Benelli
May 10, 2016·Future Microbiology·Ruchi AgrawalDeepak Kumar Saini
May 31, 2015·Applied and Environmental Microbiology·William L FranckGary Stacey
Apr 11, 2018·PloS One·Ignacio FernándezMariela Del Carmen Carrica

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.