Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia.

Schizophrenia Bulletin
Dongdong LinJingyu Liu

Abstract

Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter (GM) measures to explore the role of genetic and epigenetic variation to the brain structure changes in schizophrenia (SZ). By focusing on the reported SZ genetic risk regions, we applied a multi-stage multivariate analysis to a discovery dataset (92 SZ patients and 110 controls, blood) and an independent replication dataset (93 SZ patients and 99 controls, saliva). Two pairs of SNP-methylation components were significantly correlated (r = .48 and .35) in blood DNA, and replicated (r = .46 and .29) in saliva DNA, reflecting cross-tissue SNP cis-effects. In the discovery data, both SNP-related methylation components were also associated with one GM component primarily located in cerebellum, caudate, and thalamus. Additionally, another methylation component in NOSIP gene with significant SZ patient differences (P = .009), was associated with 8 GM components (7 with patient differences) including superior, middle, and inferior frontal gyri, superior, middle, and inferior temporal gy...Continue Reading

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Jul 29, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hannah FlachSusanne J Kühl
May 21, 2019·Journal of Cellular and Molecular Medicine·Yi-Hua LuShu-Feng Lei
Dec 2, 2018·Frontiers in Psychiatry·Jiayu ChenJingyu Liu
Dec 8, 2020·The International Journal of Neuropsychopharmacology·Błażej MisiakPaweł Karpiński
Oct 21, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Dongdong LinJingyu Liu
May 9, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Judith B M EnsinkRamon J L Lindauer

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