PMID: 8947315Nov 1, 1996Paper

Cross-tolerance between acute alcohol intoxication and endotoxemia

Alcoholism, Clinical and Experimental Research
A P Bautista, J A Spitzer

Abstract

This study tests two hypotheses: (1) prior exposure to LPS induces cross-tolerance for the hepatic effects of subsequent short-term alcohol intoxication; and (2) short-term alcohol intoxication renders the liver resistant to the effects of acute endotoxemia, resulting in reduced production of superoxide and tumor necrosis factor. In the first group of experiments, male Sprague-Dawley rats were treated intravenously with E. coli lipopolysaccharide (LPS) (0.5 mg/kg) 48 hr before they were given an intravenous bolus of ethanol (1.75 g/kg), followed by 250-300 mg/kg/hr) for 3-5 hr. Superoxide release in the perfused liver was measured after 3-hr ethanol infusion. Pretreatment with LPS attenuated ethanol-mediated superoxide anion release by the perfused liver. The stimulatory effect of phorbol myristate acetate on hepatic release of superoxide was also decreased. In the second group of experiments, rats previously treated with ethanol for 5 hr, received an intravenous injection of LPS (1 mg/kg). At 90 min after LPS, sera were collected for tumor necrosis factor alpha assay. Hepatic release of superoxide anion was determined 3 hr after LPS. Acute ethanol intoxication for 5 hr significantly reduced LPS-induced serum tumor necrosis fac...Continue Reading

References

May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A P Bautista, J J Spitzer
Jun 1, 1992·Alcoholism, Clinical and Experimental Research·G G MeadowsD S Singer
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T F TaraschiE Rubin
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May 1, 1996·Alcoholism, Clinical and Experimental Research·A P Bautista, J J Spitzer

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Citations

Nov 4, 2000·Biochemical and Biophysical Research Communications·S YamashinaR G Thurman
Jul 23, 2002·Journal of Toxicology and Environmental Health. Part a·Ramez LabibMohamed S Abdel-Rahman
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Nobuyuki EnomotoNobuhiro Sato
Jan 5, 2002·Journal of Basic and Clinical Physiology and Pharmacology·I Okulicz-KozarynK Kus
Mar 18, 2009·World Journal of Gastroenterology : WJG·Courtney S SchaffertGeoffrey M Thiele
Apr 13, 2000·International Journal of Experimental Pathology·T M Rahman, H J Hodgson
Jan 23, 1998·Alcoholism, Clinical and Experimental Research·C Rivier
Dec 31, 2005·Alcoholism, Clinical and Experimental Research·Shunhei YamashinaNobuhiro Sato
Jan 27, 2005·Alcohol·Zhi Zhong, John J Lemasters
Oct 3, 1998·Gastroenterology·J J Spitzer, A P Bautista
Mar 21, 2002·Journal of Gastroenterology and Hepatology·S C QuirozM C Gutiérrez-Ruiz
Apr 12, 2000·Journal of Gastroenterology and Hepatology·N EnomotoR G Thurman
Nov 24, 1999·The American Journal of Physiology·M D Wheeler, R G Thurman
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rubina W SaeedChristine N Metz

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