Cross-trimester repeated measures testing for Down's syndrome screening: an assessment

Health Technology Assessment : HTA
D WrightK Spencer

Abstract

To provide estimates and confidence intervals for the performance (detection and false-positive rates) of screening for Down's syndrome using repeated measures of biochemical markers from first and second trimester maternal serum samples taken from the same woman. Stored serum on Down's syndrome cases and controls was used to provide independent test data for the assessment of screening performance of published risk algorithms and for the development and testing of new risk assessment algorithms. 15 screening centres across the USA, and at the North York General Hospital, Toronto, Canada. 78 women with pregnancy affected by Down's syndrome and 390 matched unaffected controls, with maternal blood samples obtained at 11-13 and 15-18 weeks' gestation, and women who received integrated prenatal screening at North York General Hospital at two time intervals: between 1 December 1999 and 31 October 2003, and between 1 October 2006 and 23 November 2007. Repeated measurements (first and second trimester) of maternal serum levels of human chorionic gonadotrophin (hCG), unconjugated estriol (uE3) and pregnancy-associated plasma protein A (PAPP-A) together with alpha-fetoprotein (AFP) in the second trimester. Detection and false-positive r...Continue Reading

Citations

Jun 25, 2015·Pregnancy Hypertension·Geralyn Lambert-MesserlianGlenn E Palomaki
Apr 12, 2013·Current Medical Research and Opinion·Anthony S Wierzbicki, Timothy M Reynolds
Jan 13, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S AndriettiK H Nicolaides
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Jun 8, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K H NicolaidesM M Gil
Jan 5, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D WrightK H Nicolaides
Jul 14, 2017·Archives of Gynecology and Obstetrics·Karl Oliver KaganMarkus Hoopmann

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