Crossbridge and non-crossbridge contributions to tension in lengthening rat muscle: force-induced reversal of the power stroke.

The Journal of Physiology
G J PinnigerG W Offer

Abstract

Lengthening of active muscle is an essential feature of animal locomotion, but the molecular processes occurring are incompletely understood. We therefore examined and modelled tension responses to ramp stretches (5% fibre length, L0) over a wide range of velocities (0.1-10 L(0) s(-1)) of tetanized intact rat muscle fibre bundles (L0 approximately 2 mm) with a resting sarcomere length of 2.5 microm at 20 degrees C. Tension rose to a peak during stretch and decayed afterwards to a level which was higher than the prestretch tetanic tension. This residual force enhancement was insensitive to velocity. The tension rise during stretch showed an early transition (often appearing as an inflection) at approximately 1 ms. Both the stretch (L1) and the tension rise at this transition increased in proportion to velocity. A second transition, marked by a reduction in slope, occurred at a stretch of approximately 18 nm per half-sarcomere; the rise in tension at this transition increased with velocity towards a plateau. Based on analyses of the velocity dependence of the tension and modelling, we propose that the initial steep increase in tension arises from increasing strain of all attached crossbridges and that the first transition reflect...Continue Reading

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