Crossed over repair of the femoral sensory and motor branches influences N-CAM

Neuroreport
Harukazu SaitoLars B Dahlin

Abstract

N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of sensory and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair.

References

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Jan 27, 2007·Journal of Neurochemistry·Gabriele Loers, Melitta Schachner
Jun 12, 2008·International Review of Cell and Molecular Biology·Sheng T HouRobert A Smith
Sep 20, 2008·BMC Neuroscience·Harukazu Saito, Lars B Dahlin
Feb 25, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Budd A Tucker, Karen M Mearow

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Citations

Jan 1, 2013·Brain Sciences·Asa Fex Svennigsen, Lars B Dahlin
Sep 24, 2020·Cells·Sara BolívarEsther Udina

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