Crossing the embryonic midline: molecular mechanisms regulating axon responsiveness at an intermediate target

Wiley Interdisciplinary Reviews. Developmental Biology
Alexandra Neuhaus-Follini, Greg J Bashaw

Abstract

In bilaterally symmetric animals, the precise assembly of neural circuitry at the midline is essential for coordination of the left and right sides of the body. Commissural axons must first be directed across the midline and then be prevented from re-crossing in order to ensure proper midline connectivity. Here, we review the attractants and repellents that direct axonal navigation at the ventral midline and the receptors on commissural neurons through which they signal. In addition, we discuss the mechanisms that commissural axons use to switch their responsiveness to midline-derived cues, so that they are initially responsive to midline attractants and subsequently responsive to midline repellents.

References

Sep 1, 1994·Genes & Development·P L SteinP Soriano
Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
May 18, 1999·Developmental Biology·T HummelC Klämbt
Aug 26, 2000·Science·M J Galko, M Tessier-Lavigne
Feb 13, 2001·Neuron·S RajagopalanB J Dickson
Aug 31, 2002·Cell·Krystyna KelemanBarry J Dickson
Jul 4, 2003·The Journal of Biological Chemistry·Yoshihito TaniguchiSangram S Sisodia
Aug 28, 2003·Developmental Biology·Kye Won ParkDean Y Li
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vera NiederkoflerSilvia Arber
Jul 20, 2004·Nature Cell Biology·Srikanth RajagopalanStephen M Strittmatter
Oct 21, 2004·Nature Neuroscience·Weiquan LiKun-Liang Guan
Nov 24, 2004·The Journal of Cell Biology·Mayya MerianeNathalie Lamarche-Vane
Jan 20, 2005·Nature Neuroscience·Krystyna KelemanBarry J Dickson
Mar 5, 2005·Nature Neuroscience·Dimitris BourikasEsther T Stoeckli

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Citations

Jan 5, 2017·Cell Reports·Melissa Hernandez-FlemingGreg J Bashaw
Apr 20, 2019·Nature Reviews. Neuroscience·Alain Chédotal
Dec 27, 2017·Seminars in Cell & Developmental Biology·Hugo DucuingValérie Castellani
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Maud WurmserSara Ivy Wilson
Aug 21, 2020·Developmental Biology·Madhavi Gorla, Greg J Bashaw

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