Crossing the lipid divide.

The Journal of Biological Chemistry
Christian Sohlenkamp

Abstract

Archaeal membrane lipids are structurally different from bacterial and eukaryotic membrane lipids, but little is known about the enzymes involved in their synthesis. In a recent study, Exterkate et al. identified and characterized a cardiolipin synthase from the archaeon Methanospirillum hungatei. This enzyme can synthesize archaeal, bacterial, and mixed archaeal/bacterial cardiolipin species from a wide variety of substrates, some of which are not even naturally occurring. This discovery could revolutionize synthetic lipid biology, being used to construct a variety of lipids with nonnatural head groups and mixed archaeal/bacterial hydrophobic chains.

References

Dec 14, 2007·Journal of Lipid Research·Michael Schlame
May 26, 2009·Biochimica Et Biophysica Acta·Angela Corcelli
Feb 14, 2014·FEMS Yeast Research·Lisa Klug, Günther Daum
Sep 16, 2014·Chemistry & Biology·Samta JainArnold J M Driessen
Apr 12, 2015·FEMS Microbiology Reviews·Christian Sohlenkamp, Otto Geiger
Apr 25, 2021·The Journal of Biological Chemistry·Marten ExterkateArnold J M Driessen

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