Crosslinked hyaluronic acid dermal fillers: a comparison of rheological properties

Journal of Biomedical Materials Research. Part a
Samuel J Falcone, Richard A Berg

Abstract

Temporary dermal fillers composed of crosslinked hyaluronic acid (XLHA) are space filling gels that are readily available in the United States and Europe. Several families of dermal fillers based on XLHA are now available and here we compare the physical and rheological properties of these fillers to the clinical effectiveness. The XLHA fillers are prepared with different crosslinkers, using HA isolated from different sources, have different particle sizes, and differ substantially in rheological properties. For these fillers, the magnitude of the complex viscosity, |eta*|, varies by a factor of 20, the magnitude of the complex rigidity modulus, |G*|, and the magnitude of the complex compliance, |J*| vary by a factor of 10, the percent elasticity varies from 58% to 89.9%, and the tan delta varies from 0.11 to 0.70. The available clinical data cannot be correlated with either the oscillatory dynamic or steady flow rotational rheological properties of the various fillers. However, the clinical data appear to correlate strongly with the total concentration of XLHA in the products and to a lesser extent with percent elasticity. Hence, our data suggest the following correlation: dermal filler persistence = [polymer] x [% elasticity]...Continue Reading

References

Jan 3, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·A W Klein, M L Elson
Feb 24, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·P Micheels
Sep 25, 2001·Aesthetic Plastic Surgery·C Bergeret-GalleyY G Illouz
Feb 22, 2002·Journal of Biomedical Materials Research·Jon A Rowley, David J Mooney
Jun 6, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rhoda S NarinsStacy Smith
Dec 3, 2003·Aesthetic Plastic Surgery·Gottfried LemperleUlrich Charrier
Feb 26, 2004·American Journal of Clinical Dermatology·Doris J DayScott Gottlieb
Apr 17, 2004·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Tracey Hotta
Nov 17, 2004·Archives of Facial Plastic Surgery·Stephen BosniakIoannis P Glavas
Nov 30, 2005·Journal of Biomedical Materials Research. Part a·Samuel J FalconeRichard A Berg
Jan 18, 2006·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·P AndreU Zimmermann
Jan 19, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alastair CarruthersSheetal Sapra
Jan 19, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Nicholas J LoweRickie Patnaik

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Citations

May 28, 2011·Biomacromolecules·Allison N ElderNewell R Washburn
Jun 12, 2013·International Ophthalmology Clinics·Seongmu Lee, Michael T Yen
Nov 21, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joel L CohenRhoda S Narins
May 8, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jung Min Bae, Dong Won Lee
Dec 22, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Samuel J FalconeRichard A Berg
May 15, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Samuel J Falcone, Richard A Berg
Apr 21, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Katarina Edsman, Jacques Näsström
Nov 5, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Steven H DayanThomas J Gal
Nov 5, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Leonie W SchelkeH A M Neumann
Nov 5, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Gary D MonheitDavid Burkholder
Feb 18, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alexander T HillelJennifer H Elisseeff
Jul 5, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Berthold RzanyY May Ma
Jul 5, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Katarina EdsmanAnne Helander Kenne
Jul 29, 2011·Science Translational Medicine·Alexander T HillelJennifer H Elisseeff
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Fabiola MunarinMaria Cristina Tanzi
Aug 10, 2011·Clinics in Plastic Surgery·Derek Jones
Mar 26, 2010·Journal of Biomedical Materials Research. Part a·J C AntunesJ F Mano
Oct 15, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Amir FakhariCory Berkland
Aug 26, 2014·Acta Biomaterialia·Devika M VarmaSteven B Nicoll
Sep 30, 2014·Carbohydrate Polymers·Alexander KöwitschThomas Groth
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Annalisa La GattaChiara Schiraldi
Apr 24, 2015·Ophthalmic Plastic and Reconstructive Surgery·Alison A TeoAndrew R Harrison
Jan 23, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Annalisa La GattaMario De Rosa
Apr 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·W G Philipp-DormstonK Fritz
Oct 24, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Katarina L M Edsman, Åke Öhrlund
Jul 17, 2018·Aesthetic Surgery Journal·Alberto DiasproGiuseppe Sito
Sep 9, 2018·Journal of Cosmetic Dermatology·Elena FedyakovaEduardo Anitua
Oct 13, 2018·Journal of Cosmetic Dermatology·Thierry Michaud
Oct 16, 2018·Biorheology·Beatriz LázaroJulio G Prieto
Feb 17, 2018·Clinical and Translational Medicine·Steven BowmanSadanand Fulzele
Mar 19, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Won LeeEun-Jung Yang
Apr 2, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sébastien PierreAude Bernardin
May 26, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Katarina Edsman, Anne Helander Kenne
Jan 25, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Marcos BorrellAhmet Tezel

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