Crosslinking of tRNAs by the carcinostatic agent dirhodium tetraacetate

Journal of Biomolecular Structure & Dynamics
J R Rubin, M Sundaralingam

Abstract

A crystalline complex of yeast tRNA(phe) and dirhodium tetraacetate (DRTA) was prepared and its X-ray structure determined. The bifunctional DRTA forms an intermolecular cross-link between the N(1) position of adenine A36 in the anticodon triplet and possibly a ribose hydroxyl group of residue A76 at the 3' terminus of a symmetry related tRNA molecule. The rhodium complex apparently shows a preference for binding to the N(1) position of adenine in a single strand region of the tRNA molecule.

Citations

Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·J R Rubin, M Sundaralingam
Aug 28, 2003·Journal of the American Chemical Society·Helen T ChifotidesKim R Dunbar
Dec 23, 2003·Inorganic Chemistry·Helen T ChifotidesKim R Dunbar

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