Crossmatch-compatible platelets improve corrected count increments in patients who are refractory to randomly selected platelets

Transfusion
A B Gelb, A D Leavitt

Abstract

HLA-matched platelets and crossmatch-compatible platelets are used to support thrombocytopenic patients who are refractory to randomly selected platelets. Data supporting the effectiveness of crossmatch-compatible platelets are limited, being essentially restricted to the subset of refractory patients previously shown to be alloimmunized. The authors' hospital does not test for alloimmunization. To determine the effectiveness of crossmatch-compatible platelets in an unselected group of refractory patients, the use of such platelets for all patients who are refractory to random-donor platelets was reviewed. All patients who received crossmatch-compatible platelets between January 1991 and May 1994 were retrospectively reviewed. All study patients were refractory to random-donor platelets, having two consecutive corrected count increments (CCIs) of < 10,000. A solid-phase red cell adherence method was used for platelet crossmatching, and CCI was used to monitor the effectiveness of each platelet transfusion. A total of 475 crossmatch-compatible platelet components were administered to 66 evaluable patients who were refractory to random-donor platelets. A significant improvement was found in the mean CCI when crossmatch-compatible...Continue Reading

Citations

Nov 8, 2002·Indian Journal of Pediatrics·V P Choudhry
May 22, 2003·Thrombosis Research·Mikael TranholmMorris A Blajchman
Dec 20, 1999·Transfusion Medicine Reviews·L A Chambers, J H Herman
Mar 12, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Dan A Waxman
Apr 19, 2002·Transfusion·Satoshi SaitoHiroo Maeda
Jun 17, 2014·Blood Transfusion = Trasfusione Del Sangue·Osama S SalamaWesam E Elderiny
May 30, 2013·Hematology/oncology Clinics of North America·Perumal Thiagarajan, Vahid Afshar-Kharghan
Jul 14, 2010·Seminars in Hematology·Jeffrey BryanHagop Kantarjian
Mar 17, 2007·Cancer·Hagop KantarjianJoseph Leveque
Apr 25, 2007·Acta Clinica Belgica·A BoslyD Sondag
Feb 12, 2011·Journal of Clinical Apheresis·Douaa SayedMuhammed R Khalaf
Sep 17, 2013·Transfusion·Ralph R VassalloUNKNOWN International Collaboration for Guideline Development, Implementation and Evaluation for Transfusion Therapies
Apr 27, 2000·Transfusion Medicine Reviews·E Delaflor-Weiss, P D Mintz
Jul 27, 2000·American Journal of Hematology·K R MeehanK A Schulman
Dec 11, 2019·Transfusion·Jenna WadeHarold C Sullivan
Mar 17, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Simon KingsleyDaniel Dolly
Sep 30, 2017·Transfusion·Justin E JuskewitchJustin D Kreuter
Apr 10, 2003·Archives of Pathology & Laboratory Medicine·Ronald A SacherUNKNOWN College of American Pathologists.Transfusion Medicine Resource Committee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.