Mar 31, 2020

Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro

BioRxiv : the Preprint Server for Biology
Karl Jonas HollensteinerNicasio Mancini

Abstract

While the SARS-CoV-2 pandemic is hardly hitting the world, it is of extreme importance that significant in vitro observations guide the quick set up of clinical trials. In this study, we evidence that the anti-SARS-CoV2 activity of a clinically achievable hydroxychloroquine concentration is maximized only when administered before and after the infection of Vero E6 cells. This strongly suggests that only a combined prophylactic and therapeutic use of hydroxychloroquine may be effective in limiting viral replication in patients.

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Positioning Attribute
Midline (Qualifier Value)
Psychometrics
Ferrets
Right
Midline Cell Component
Domestic Polecats
Visual Stimulus
Maximum Likelihood Estimation
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