Crossover from picosecond collective to single particle dynamics defines the mechanism of lateral lipid diffusion

Biochimica Et Biophysica Acta. Biomembranes
Dima BolmatovMikhail Zhernenkov

Abstract

It has been widely accepted that the thermally excited motions of the molecules in a cell membrane is the prerequisite for a cell to carry its biological functions. On the other hand, the detailed mapping of the ultrafast picosecond single-molecule and the collective lipid dynamics in a cell membrane remains rather elusive. Here, we report all-atom molecular dynamics simulations of a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine bilayer over a wide range of temperature. We elucidate a molecular mechanism underlying the lateral lipid diffusion in a cell membrane across the gel, rippled, and liquid phases using an analysis of the longitudinal and transverse current correlation spectra, the velocity auto-correlation functions, and the molecules mean square displacements. The molecular mechanism is based on the anomalous ultrafast vibrational properties of lipid molecules at the viscous-to-elastic crossover. The macroscopic lipid diffusion coefficients predicted by the proposed diffusion model are in a good agreement with experimentally observed values. Furthermore, we unveil the role of water confined at the water-lipid interface in triggering collective vibrations in a lipid bilayer.

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Citations

Dec 23, 2019·The Journal of Chemical Physics·V E Zakhvataev
Feb 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Dmytro SoloviovMikhail Zhernenkov
Oct 8, 2020·Soft Matter·Dima BolmatovMaxim O Lavrentovich
Mar 10, 2020·Biochimica Et Biophysica Acta. Biomembranes·Dima BolmatovJohn Katsaras
Sep 28, 2020·Chemistry and Physics of Lipids·Dima BolmatovMaxim O Lavrentovich
Jul 3, 2021·International Journal of Molecular Sciences·Roman G Efremov
Sep 19, 2020·Chemistry and Physics of Lipids·Jacob J KinnunJohn Katsaras
Aug 31, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Dima BolmatovJohn Katsaras
Apr 8, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Dima BolmatovJohn Katsaras
Oct 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Dipankar MondalNilmoni Sarkar

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