Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation.

Current Biology : CB
Elisabeth AltendorferMonica P Colaiácovo

Abstract

Interhomolog crossovers (COs) are a prerequisite for achieving accurate chromosome segregation during meiosis [1, 2]. COs are not randomly positioned, occurring at distinct genomic intervals during meiosis in all species examined [3-10]. The role of CO position as a major determinant of accurate chromosome segregation has not been previously directly analyzed in a metazoan. Here, we use spo-11 mutants, which lack endogenous DNA double-strand breaks (DSBs), to induce a single DSB by Mos1 transposon excision at defined chromosomal locations in the C. elegans germline and show that the position of the resulting CO directly affects the formation of distinct chromosome subdomains during meiotic chromosome remodeling. CO formation in the typically CO-deprived center region of autosomes leads to premature loss of sister chromatid cohesion and chromosome missegregation, whereas COs at an off-centered position, as in wild type, can result in normal remodeling and accurate segregation. Ionizing radiation (IR)-induced DSBs lead to the same outcomes, and modeling of IR dose-response reveals that the CO-unfavorable center region encompasses up to 6% of the total chromosome length. DSBs proximal to telomeres rarely form COs, likely because o...Continue Reading

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Citations

Sep 5, 2020·PLoS Genetics·Jeremy A HollisDiana E Libuda
Oct 1, 2020·The Journal of Cell Biology·James N BrandtYumi Kim
Apr 8, 2020·Current Biology : CB·Stacie E Hughes, R Scott Hawley
Mar 11, 2021·Current Biology : CB·Cathleen M Lake, R Scott Hawley
Apr 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Saravanapriah NadarajanMonica P Colaiácovo
Jul 17, 2021·Cell Cycle·James N Brandt, Yumi Kim

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