Crosstalk among Epigenetic Pathways Regulates Neurogenesis.

Frontiers in Neuroscience
Emily M JobeXinyu Zhao

Abstract

The process of neurogenesis includes neural stem cell proliferation, fate specification, young neuron migration, neuronal maturation, and functional integration into existing circuits. Although neurogenesis occurs largely during embryonic development, low levels but functionally important neurogenesis persists in restricted regions of the postnatal brain, including the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone of the lateral ventricles. This review will cover both embryonic and adult neurogenesis with an emphasis on the latter. Of the many endogenous mediators of postnatal neurogenesis, epigenetic pathways, such as mediators of DNA methylation, chromatin remodeling systems, and non-coding RNA modulators, appear to play an integral role. Mounting evidence shows that such epigenetic factors form regulatory networks, which govern each step of postnatal neurogenesis. In this review, we explore the emerging roles of epigenetic mechanisms particularly microRNAs, element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF), polycomb proteins, and methyl-CpG bindings proteins, in regulating the entire process of postnatal and adult neurogenesis. We further summarize...Continue Reading

Citations

Dec 19, 2012·Epigenomics·Marie-Claude SenutDouglas Ruden
Apr 2, 2013·Cellular and Molecular Life Sciences : CMLS·R C Agis-Balboa, A Fischer
Feb 6, 2016·International Journal of Molecular Sciences·Bhairavi SrinageshwarJulien Rossignol
Dec 8, 2015·Molecular and Cellular Neurosciences·Anita Bhattacharyya, Xinyu Zhao
Jan 7, 2016·Frontiers in Neuroscience·Nikolaos MitrousisOla Hermanson
Jul 19, 2013·Journal of Neuropathology and Experimental Neurology·Xian Shuang LiuZheng Gang Zhang
Jun 18, 2015·Computational and Structural Biotechnology Journal·Federico Andreoli, Alberto Del Rio
Apr 2, 2016·Neural Plasticity·Yuqin YeXiaosheng He
Aug 2, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Eva Díaz-GuerraCarlos Vicario-Abejón
Oct 10, 2013·Journal of Neurochemistry·Yi-Tzang Tsai, Robert K Yu
Feb 28, 2014·IUBMB Life·Siddhartha Roy, Tapas K Kundu
Mar 15, 2015·Developmental Biology·Crystal E Love, Victoria E Prince
May 26, 2015·Nature Genetics·Ya-Chun ChenJan Senderek
Jun 29, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Jennifer ClarkeNagi G Ayad
Dec 18, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Miguel Alejandro Lopez-Ramirez, Stefania Nicoli
Apr 22, 2015·Nature Reviews. Neurology·Ximena Paez-ColasanteEva L Feldman
Nov 19, 2013·Neurobiology of Aging·Daniel L Van den HoveBart P F Rutten
May 24, 2014·Drug Discovery Today·Federico Andreoli, Alberto Del Rio
Nov 18, 2014·Frontiers in Genetics·Herah HansjiMarjan E Askarian-Amiri
Sep 11, 2014·Frontiers in Genetics·Marisol ResendizFeng C Zhou
Aug 20, 2016·Glycoconjugate Journal·Yutaka ItokazuRobert K Yu
Mar 8, 2017·Genes·Haifa KassisZheng Gang Zhang
Jun 25, 2017·Neuroscience and Biobehavioral Reviews·Angela IannitelliGiuseppe Bersani
Jun 15, 2016·Scientific Reports·David BrileyMaria-Adelaide Micci
Feb 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathleen C PageEndla K Anday
Oct 27, 2015·Neurochemical Research·Yi-Tzang TsaiRobert K Yu
May 20, 2016·Cold Spring Harbor Perspectives in Medicine·Christophe Bernard
Jun 8, 2017·Frontiers in Molecular Neuroscience·Robert BronsteinStella E Tsirka
Jul 3, 2016·Cold Spring Harbor Perspectives in Biology·Stavros Lomvardas, Tom Maniatis
Dec 14, 2018·Biomedical Reports·Si-Jing FanLian Liu
May 5, 2016·Cold Spring Harbor Perspectives in Biology·Jenny Hsieh, Xinyu Zhao
May 17, 2018·Brain Plasticity·Pascal BielefeldCarlos P Fitzsimons
Jun 2, 2020·Frontiers in Cellular Neuroscience·Ximena Paez-ColasanteEva L Feldman
Nov 20, 2016·Epigenomics·Patricia Marie GarayShigeki Iwase
Nov 21, 2018·Frontiers in Neuroscience·Laura StappertOliver Brüstle

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
ubiquitination
transgenic
histone acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.