Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives.

Molecular Cancer
Xiaoqi MaoSi Shi

Abstract

Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tumor growth, angiogenesis, invasion and metastasis, along with extracellular matrix (ECM) remodeling and even chemoresistance. Numerous previous studies have confirmed the critical role of the interaction between CAFs and tumor cells in tumorigenesis and development. However, recently, the mutual effects of CAFs and the tumor immune microenvironment (TIME) have been identified as another key factor in promoting tumor progression. The TIME mainly consists of distinct immune cell populations in tumor islets and is highly associated with the antitumor immunological state in the TME. CAFs interact with tumor-infiltrating immune cells as well as other immune components within the TIME via the secretion of various cytokines, growth factors, chemokines, exosomes and other effector molecules, consequently shaping an immunosuppressive TME that enables cancer cells to evade surveillance of the immune system. In-depth studies of CAFs and immune microenvironment interactions, particularly the...Continue Reading

References

Mar 10, 2001·Experimental Cell Research·B Elenbaas, R A Weinberg
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D BaramY A Mekori
Apr 22, 2003·Nature Medicine·Tyler J CurielWeiping Zou
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Simon S BrackDario Neri
Jun 24, 2006·The Journal of Clinical Investigation·Markus LoefflerRalph A Reisfeld
Jul 13, 2006·Human Molecular Genetics·Feng-Chun YangD Wade Clapp
Oct 3, 2006·Cancer Biology & Therapy·Vanina MedinaElena S Rivera
Jan 4, 2007·The Journal of Clinical Investigation·M Bishr OmaryStephen J Pandol
Jan 18, 2007·Journal of Cellular Biochemistry·Hanchen LiJeanmarie Houghton
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael R NazarethRichard B Bankert
Jul 17, 2007·Cancer Letters·Dayanidhi RamanAnn Richmond
Oct 5, 2007·Nature·Antoine E KarnoubRobert A Weinberg
Jan 24, 2008·The American Journal of Dermatopathology·Trevor W BeerKevin Murray
Mar 28, 2008·Immunological Reviews·Paola AllavenaAlberto Mantovani
Jul 16, 2008·Molecular Aspects of Medicine·Gillian Murphy, Hideaki Nagase
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elinborg OstermannGuenther R Adolf
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rossana TrottaMichael A Caligiuri
Sep 18, 2008·British Journal of Cancer·S PotentaR Kalluri
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jessica MårlindDario Neri
Mar 12, 2009·Human Immunology·Nicole Suciu-FocaRaffaello Cortesini
Apr 15, 2009·Nature Reviews. Immunology·Gabriel A Rabinovich, Marta A Toscano
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Aug 1, 2009·BMC Cancer·Robert M EagerJohn Nemunaitis
Nov 26, 2009·Cell·Kandice R LeventalValerie M Weaver
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mirna BalsamoMassimo Vitale
Dec 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emeline Van GoethemVéronique Le Cabec
Mar 20, 2010·The Journal of Clinical Investigation·Jadwiga JablonskaSiegfried Weiss
Jul 10, 2010·The American Journal of Pathology·Anna JohanssonAnders Bergh
Jul 10, 2010·Nature Reviews. Immunology·Richard A FlavellPaula Licona-Limón
Sep 25, 2010·Nature Reviews. Immunology·Lydia Sorokin
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yasushi KojimaAkira Orimo

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