Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

Cell Metabolism
Robert CaesarFredrik Bäckhed

Abstract

Dietary lipids may influence the abundance of circulating inflammatory microbial factors. Hence, inflammation in white adipose tissue (WAT) induced by dietary lipids may be partly dependent on their interaction with the gut microbiota. Here, we show that mice fed lard for 11 weeks have increased Toll-like receptor (TLR) activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition. Trif(-/-) and Myd88(-/-) mice are protected against lard-induced WAT inflammation and impaired insulin sensitivity. Experiments in germ-free mice show that an interaction between gut microbiota and saturated lipids promotes WAT inflammation independent of adiposity. Finally, we demonstrate that the chemokine CCL2 contributes to microbiota-induced WAT inflammation in lard-fed mice. These results indicate that gut microbiota exacerbates metabolic inflammation through TLR signaling upon challenge with a diet rich in saturated lipids.

Associated Clinical Trials

References

Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Britta WlotzkaSven Klussmann
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kathrin S MichelsenMoshe Arditi
Jul 19, 2005·The British Journal of Nutrition·Francisco GuarnerLorenzo Morelli
Dec 13, 2005·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Jul 13, 2007·Journal of the American Society of Nephrology : JASN·Onkar KulkarniHans-Joachim Anders
Nov 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·Onkar KulkarniHans-Joachim Anders
May 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J D Buckley, P R C Howe
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Dec 31, 2009·Journal of Lipid Research·Vidya R VelagapudiFredrik Bäckhed
May 6, 2010·The British Journal of Nutrition·Christine K FleissnerMichael Blaut
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Li YuShangwu Chen
Aug 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sylvie RabotChieh J Chou
Sep 4, 2010·Gastroenterology Research and Practice·Jane J Kim, Dorothy D Sears
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martin A KriegelDiane Mathis
Jun 8, 2012·Science·Lora V HooperAndrew J Macpherson
Jul 7, 2012·Journal of Lipid Research·Shurong HuangDaniel H Hwang
Nov 14, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Karen P ScottSylvia H Duncan
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Aug 3, 2013·The Journal of Allergy and Clinical Immunology·Chengcheng Jin, Richard A Flavell

❮ Previous
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Citations

Feb 9, 2016·Cell Metabolism·Daniel A WinerShawn Winer
Nov 7, 2015·Cellular and Molecular Life Sciences : CMLS·Paige V BauerFrank A Duca
Jan 11, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Benoit Chassaing, Andrew T Gewirtz
Dec 1, 2015·Molecular Nutrition & Food Research·Jennifer M MonkLindsay E Robinson
Dec 10, 2015·Nature Medicine·Beng San Yeoh, Matam Vijay-Kumar
Dec 1, 2015·Seminars in Immunology·Joanna R DiSpirito, Diane Mathis
Mar 31, 2016·International Journal of Molecular Sciences·David HoughtonMichael Trenell
Apr 14, 2016·Journal of Internal Medicine·T Arora, F Bäckhed
Mar 8, 2016·American Journal of Respiratory Cell and Molecular Biology·Stephanie A Shore, Youngji Cho
Feb 26, 2016·Postgraduate Medical Journal·Elaine PattersonCatherine Stanton
Jun 9, 2016·BioResearch Open Access·Walter H MoosKosta Steliou
Jun 4, 2016·Nature Reviews. Rheumatology·Shahla Abdollahi-RoodsazJose U Scher
Jun 9, 2016·Nature Reviews. Gastroenterology & Hepatology·Christopher LeungPeter W Angus
Jun 16, 2016·Cell Metabolism·Marika ZiętakFredrik Bäckhed
Jun 21, 2016·Cell Metabolism·Annika WahlströmFredrik Bäckhed
Sep 13, 2016·Molecular Metabolism·Stavros BashiardesEran Elinav
Jul 8, 2016·Nature·Justin L Sonnenburg, Fredrik Bäckhed
Jul 16, 2016·The Journal of Physiology·Aafke W F Janssen, Sander Kersten
Sep 14, 2016·Brain, Behavior, and Immunity·Daniel J DavisCatherine H Gillespie
Sep 19, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jensen H C YiuConnie W Woo
Jun 12, 2016·Molecular Nutrition & Food Research·Kevin J PortuneYolanda Sanz
Oct 28, 2016·Nature Genetics·Marc Jan BonderAlexandra Zhernakova
Oct 27, 2016·Critical Reviews in Microbiology·Yang HeJunshuai Wang
Nov 14, 2016·Gastroenterology Clinics of North America·Kristina B MartinezEugene B Chang
Dec 3, 2016·Nature Reviews. Cardiology·Annika Lindskog Jonsson, Fredrik Bäckhed
Dec 14, 2016·Scientific Reports·Mariann I LasseniusMarkku Lehto
Dec 15, 2016·Gut Microbes·Amy M SheflinTiffany L Weir
Oct 28, 2016·Journal of Diabetes·Hagit ShapiroEran Elinav
Jan 20, 2017·Molecular Nutrition & Food Research·Toshihiro SakuraiAlan T Remaley
Mar 7, 2017·Nature Reviews. Immunology·Maayan LevyEran Elinav
Feb 16, 2017·Journal of Pineal Research·Pengfei XuYonggong Zhai
May 20, 2017·The ISME Journal·Tulika AroraFredrik Bäckhed
Apr 9, 2017·The Journal of Biological Chemistry·Kimberly A KrautkramerJohn M Denu
Jun 2, 2017·Annals of the American Thoracic Society·Benjamin T SurattUNKNOWN Allergy, Immunology, and Inflammation Assembly
Apr 14, 2017·Holistic Nursing Practice·Stephanie Maxine Ross
Jun 23, 2016·Journal of Lipid Research·Meric Erikci Ertunc, Gökhan S Hotamisligil
Jan 20, 2016·Journal of Lipid Research·Robert CaesarFredrik Bäckhed

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Methods Mentioned

BETA
Illumina sequencing

Software Mentioned

GraphPad Prism

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