Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases.

Frontiers in Immunology
Yuhao JiaoXuan Zhang

Abstract

The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be related to various alterations of the immune system. This review focuses on the reciprocal relationship between gut microbiota and innate immunity compartment, with emphasis on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes. From a clinical perspective, the review gives a possible explanation of how the "gut microbiota-innate immunity" axis might contribute to the pathogenesis of autoimmune diseases like rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus.

References

Jul 1, 1966·Journal of Gerontology·H A GordonB S Wostmann
Apr 1, 1997·International Immunology·S AdachiS Nishikawa
Jan 1, 1997·Lupus·F M Erkeller-YukselD A Isenberg
Apr 25, 2000·Science·J Lederberg
Oct 25, 2000·Trends in Microbiology·R Medzhitov, C Janeway
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiromasa HamadaHiromichi Ishikawa
Apr 2, 2003·Nature Reviews. Immunology·Allan McI Mowat
Nov 1, 1964·Journal of Bacteriology·R J GIBBONSB KAPSIMALIS
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ki-Jong RheeKatherine L Knight
Dec 1, 2004·Annual Review of Genetics·Christian S RiesenfeldJo Handelsman
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Oct 12, 2005·The Journal of Experimental Medicine·Bengt Johansson-LindbomWilliam W Agace
Dec 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shannon J TurleyChristophe Benoist
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Jul 1, 1970·Infection and Immunity·M Pollard, N Sharon
Jun 3, 2006·Science·Steven R GillKaren E Nelson
Nov 18, 2006·Science·J Rodrigo MoraUlrich H von Andrian
Mar 24, 2007·Nature Reviews. Immunology·Hiroshi Takayanagi
Sep 1, 2007·Arthritis and Rheumatism·Shahla Abdollahi-RoodsazWim B van den Berg
Oct 4, 2007·International Journal of Systematic and Evolutionary Microbiology·Jongsik ChunYoung-Woon Lim
Oct 19, 2007·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 7, 2007·The Journal of Clinical Investigation·Shahla Abdollahi-RoodsazWim B van den Berg
May 24, 2008·Science·Ruth E LeyJeffrey I Gordon
May 27, 2008·Genome Research·Elizabeth A GriceJulia A Segre
Jul 25, 2008·Blood·Michael A Caligiuri
Dec 17, 2008·Mucosal Immunology·P BrandtzaegM W Russell
Dec 23, 2008·Mucosal Immunology·K R R Siddiqui, F Powrie

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Citations

Sep 29, 2020·Frontiers in Immunology·Wenjie Liang, Julien Diana
Mar 3, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Camilla ViriliMarco Centanni
Feb 20, 2021·Journal of Neuroimmunology·Ziaur Rahman, Manoj P Dandekar
Apr 18, 2021·Current Rheumatology Reports·Rongli LiXuan Zhang
Apr 28, 2021·Pediatric Rheumatology Online Journal·Anders ÖmanLillemor Berntson
Nov 14, 2020·International Journal of Molecular Sciences·Jayoon MoonMee Kum Kim
Jun 29, 2021·Frontiers in Immunology·Xiaojing ChuYang Li
Aug 17, 2021·Frontiers in Immunology·Gislane Lelis Vilela de OliveiraAlessio Fasano
Aug 23, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ziyu Wang, Jun Wang

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Methods Mentioned

BETA
IEC
IECs
immunoprecipitation
histone acetylation
biopsy

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.